Diagnostic efficacy of CA 15-3 and CEA in the early detection of metastatic breast cancer-A retrospective analysis of kinetics on 743 breast cancer patients
Diagnostic efficacy of CA 15-3 and CEA in the early detection of metastatic breast cancer-A retrospective analysis of kinetics on 743 breast cancer patients
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DOI：
10.1016/j.cca.2015.06.022
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发表时间：
2015-08-25
影响因子：
5
通讯作者：
Di Gioia, Dorit
中科院分区：
文献类型：
--
作者：
Stieber, Petra;Nagel, Dorothea;Di Gioia, Dorit
目的：我们研究了CEA和CA 15-3动力学的诊断能力，为转移性疾病的早期检测比较固定cut-off values.Methods：在一项回顾性分析，共743例早期乳腺癌和可用的基线值CEA和CA 15-3被列入。一个可重复的增加100%的单一或组合标记被认为是一个强有力的指标转移diseases.Results：187例患者发生转移性疾病和556仍然无病。基于肿瘤标志物动力学，我们达到了两种生物标志物的>98%的特异性和单独CEA的40.6%、单独CA 15-3的55.6%和两种标志物的组合的66.3%的灵敏度。使用固定的截止值（CEA：4 ng/mL，CA 15-3：30 U/mL），我们最终得出CEA和CA 15-3组合的特异性为86.3%，灵敏度为70.6%。使用较高的截止值（CEA：6 ng/mL，CA 15-3：60 U/mL），我们达到了96.9%的特异性和49.7%的灵敏度为combination.Conclusion：我们得出结论，这些标志物的解释，在后续使用个人的基线值和动力学导致显着的特异性和灵敏度的上级配置文件。(C)2015爱思唯尔B. V.保留所有权利。
Objective: We investigated the diagnostic capacity of CEA and CA 15-3 kinetics for the early detection of metastatic disease in comparison to fixed cut off values.Methods: In a retrospective analysis, a total of 743 patients with early breast cancer and available baseline values of CEA and CA 15-3 were included. A reproducible increase of 100% of single or combined markers was considered as a strong indicator of metastatic disease.Results: 187 patients developed metastatic disease and 556 remained disease-free. On the basis of tumor marker kinetics, we reached a specificity of >98% for both biomarkers and a sensitivity of 40.6% for CEA alone, 55.6% for CA 15-3 alone and 66.3% for the combination of both markers. Using fixed cut-off values (CEA: 4 ng/mL, CA 15-3: 30 U/mL) we ended up with a specificity of 86.3% and a sensitivity of 70.6% for the combination of CEA and CA 15-3. Using higher cut-off values (CEA: 6 ng/mL, CA 15-3: 60 U/mL) we reached a specificity of 96.9% and a sensitivity of 49.7% for the combination.Conclusion: We conclude that the interpretation of these markers in follow-up using individual baseline values and kinetics leads to a significant superior profile of specificity and sensitivity. (C) 2015 Elsevier B.V. All rights reserved.