Cord Blood as a Source of Natural Killer Cells.
Cord Blood as a Source of Natural Killer Cells.
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DOI：
10.3389/fmed.2015.00093
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发表时间：
2015
影响因子：
3.9
通讯作者：
Rezvani K
中科院分区：
文献类型：
--
作者：
Mehta RS;Shpall EJ;Rezvani K
脐带血(CB)作为造血干细胞移植(HSCT)的移植物来源具有许多独特的优势。脐带血移植(CBT)后复发和移植物抗宿主疾病的风险低于具有类似人类白细胞抗原错配程度的其他移植物来源后的典型观察结果。自然杀伤(NK)细胞在先天免疫和获得性免疫中具有明确的作用，是HSCT和CBT后最早重建的淋巴细胞，在预防早期复发方面发挥着重要作用。在这篇文章中，我们重点介绍了CB NK细胞在移植和过继免疫治疗中的应用。首先，我们将描述与外周血相比，脐带血中NK细胞的表型和功能特征的差异。然后，我们将回顾在使用静止的CB NK细胞进行过继免疫治疗方面所面临的一些障碍，并讨论克服这些障碍的方法。我们将对目前有关杀伤细胞免疫球蛋白样受体配基错配和CBT术后预后的文献进行综述。最后，我们将谈到目前在细胞免疫治疗中使用CB NK细胞的策略。
Cord blood (CB) offers several unique advantages as a graft source for hematopoietic stem cell transplantation (HSCT). The risk of relapse and graft vs. host disease after cord blood transplantation (CBT) is lower than what is typically observed after other graft sources with a similar degree of human leukocyte antigen mismatch. Natural killer (NK) cells have a well-defined role in both innate and adaptive immunity and as the first lymphocytes to reconstitute after HSCT and CBT, and they play a significant role in protection against early relapse. In this article, we highlight the uses of CB NK cells in transplantation and adoptive immunotherapy. First, we will describe differences in the phenotype and functional characteristics of NK cells in CB as compared with peripheral blood. Then, we will review some of the obstacles we face in using resting CB NK cells for adoptive immunotherapy, and discuss methods to overcome them. We will review the current literature on killer-cell immunoglobulin-like receptors ligand mismatch and outcomes after CBT. Finally, we will touch on current strategies for the use of CB NK cells in cellular immunotherapy.