The subthalamic nucleus exerts opposite control on cocaine and 'natural' rewards
The subthalamic nucleus exerts opposite control on cocaine and 'natural' rewards
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DOI：
10.1038/nn1429
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发表时间：
2005-04-01
影响因子：
25
通讯作者：
Amalric, M
中科院分区：
文献类型：
--
作者：
Baunez, C;Dias, C;Amalric, M
治疗药物成瘾者的一个挑战是防止他们对药物的病态动机，而不损害他们对天然药物的一般情感状态。在这里，我们已经表明，丘脑底核的离散病变大大降低了大鼠对可卡因的动机，同时增加了食物奖励。丘脑底核是控制基底神经节输出的关键结构，因此能够反向调节“自然”奖励和滥用药物对行为的影响。调节丘脑底核的活动可能被证明是治疗可卡因成瘾的新靶点。
A challenge in treating drug addicts is preventing their pathological motivation for the drug without impairing their general affective state toward natural reinforcers. Here we have shown that discrete lesions of the subthalamic nucleus greatly decreased the motivation of rats for cocaine while increasing it for food reward. The subthalamic nucleus, a key structure controlling basal ganglia outputs, is therefore able to oppositely modulate the effect of 'natural' rewards and drugs of abuse on behavior. Modulating the activity of the subthalamic nucleus might prove to be a new target for the treatment of cocaine addiction.