Neural and immunological synaptic relations
Neural and immunological synaptic relations
复制标题
DOI：
10.1126/science.1076386
复制
发表时间：
2002-10-25
期刊：
影响因子：
56.9
通讯作者：
Colman, DR
中科院分区：
文献类型：
--
作者：
Dustin, ML;Colman, DR
突触是两个细胞之间的稳定的粘附连接，信息通过定向分泌传递。神经系统和免疫系统利用这些特化的细胞表面接触来在其组成细胞群之间直接传递和传递高度受控的分泌信号。这些突触类型中的每一种都是围绕微区结构构建的，微区结构包括被粘附结构域包围的胞吐和胞吞的中心活性区。可以结合到活动区中和周围的表面分子有助于调节突触的功能状态。
A synapse is a stable adhesive junction between two cells across which information is relayed by directed secretion. The nervous system and immune system utilize these specialized cell surface contacts to directly convey and transduce highly controlled secretory signals between their constituent cell populations. Each of these synaptic types is built around a microdomain structure comprising central active zones of exocytosis and endocytosis encircled by adhesion domains. Surface molecules that may be incorporated into and around the active zones contribute to modulation of the functional state of the synapse.