Noise induced hearing loss impairs spatial learning/memory and hippocampal neurogenesis in mice.
Noise induced hearing loss impairs spatial learning/memory and hippocampal neurogenesis in mice.
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DOI：
10.1038/srep20374
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发表时间：
2016-02-04
影响因子：
4.6
通讯作者：
Wang J
中科院分区：
文献类型：
--
作者：
Liu L;Shen P;He T;Chang Y;Shi L;Tao S;Li X;Xun Q;Guo X;Yu Z;Wang J
听力损失与老年人认知能力下降有关，被认为是痴呆症的一个独立危险因素。获得性感音神经性听力损失最常见的原因之一是暴露于过度的噪音，这已经被发现会损害人类和动物模型的学习能力和认知表现。噪音暴露也被发现抑制海马体的神经发生。然而，这种影响主要归因于噪音对认知大脑的氧化应激。在本研究中，年轻的成年CBA/CAJ小鼠（1.5 - 2个月大）短暂暴露在高声级环境中，造成中度至重度听力损失。在血液和海马中，噪声暴露后只观察到短暂的氧化应激。然而，噪声暴露3个月后，空间学习/记忆出现缺陷。此外，这种缺陷与听力损失的程度有关，并与海马体中神经发生的减少有关。我们认为，观察到的影响可能是由于听力损失而不是最初的氧化应激，氧化应激只持续了很短的时间。
Hearing loss has been associated with cognitive decline in the elderly and is considered to be an independent risk factor for dementia. One of the most common causes for acquired sensorineural hearing loss is exposure to excessive noise, which has been found to impair learning ability and cognitive performance in human subjects and animal models. Noise exposure has also been found to depress neurogenesis in the hippocampus. However, the effect is mainly attributed to the oxidant stress of noise on the cognitive brain. In the present study, young adult CBA/CAJ mice (between 1.5 and 2 months of age) were briefly exposed a high sound level to produce moderate-to-severe hearing loss. In both the blood and hippocampus, only transient oxidative stress was observed after noise exposure. However, a deficit in spatial learning/memory was revealed 3 months after noise exposure. Moreover, the deficit was correlated with the degree of hearing loss and was associated with a decrease in neurogenesis in the hippocampus. We believe that the observed effects were likely due to hearing loss rather than the initial oxidant stress, which only lasted for a short period of time.