Neurotrophin 4/5 is a trophic factor for mammalian facial motor neurons.
Neurotrophin 4/5 is a trophic factor for mammalian facial motor neurons.
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Neurotropin 4/5 是哺乳动物面部运动神经元的营养因子。
DOI：
10.1073/pnas.91.8.3304
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发表时间：
1994
影响因子：
11.1
通讯作者：
Rosenthal,A
中科院分区：
文献类型：
--
作者：
Koliatsos,VE;Cayouette,MH;Berkemeier,LR;Clatterbuck,RE;Price,DL;Rosenthal,A
发育中的运动神经元的存活取决于骨骼肌和中枢神经系统内细胞分泌的因子。虽然神经生长因子蛋白家族[神经营养因子（NT）]的几个成员能够在体外维持发育中的大鼠运动神经元，但只有脑源性神经营养因子已被证明对体内运动神经元的存活具有显著影响。在本研究中，我们证明，NT-4/5也防止损伤诱导的新生大鼠面运动神经元的死亡。此外，面部运动神经元表达NT-4/5的功能性受体，而mRNA编码的NT-4/5可以在整个胚胎和出生后的生活中检测到。因此，NT-4/5和脑源性神经营养因子可能是面运动神经元的生理存活因子，并可作为运动神经元疾病的治疗剂。
The survival of developing motor neurons depends on factors secreted from skeletal muscles and from cells within the central nervous system. Although several members of the nerve growth factor protein family [neurotrophins (NTs)] are able to maintain developing rat motor neurons in vitro, only the brain-derived neurotrophic factor has been shown to have significant effects on the survival of motor neurons in vivo. In the present study, we demonstrate that NT-4/5 also prevents injury-induced death of facial motor neurons in neonatal rats. Furthermore, facial motor neurons express a functional receptor for NT-4/5, whereas mRNA-encoding NT-4/5 can be detected in their environment throughout embryonic and postnatal life. Thus, both NT-4/5 and brain-derived neurotrophic factor may be physiological survival factors for facial motor neurons and may serve as therapeutic agents for motor neuron disease.