Identification of Kidney Transplant Recipients with Coronavirus Disease 2019
Identification of Kidney Transplant Recipients with Coronavirus Disease 2019
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DOI：
10.1016/j.eururo.2020.03.030
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发表时间：
2020-06-01
期刊：
影响因子：
23.4
通讯作者：
Wang, Zhen-Di
中科院分区：
文献类型：
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作者：
Zhang, Hui;Chen, Yan;Wang, Zhen-Di
2019冠状病毒病（COVID-19）是一种新型致命传染病，对全球卫生安全构成威胁。病例数量迅速增加，但没有关于肾移植（KTx）受者感染COVID-19的数据。为了介绍感染COVID-19的KTx接受者的流行病学，临床和治疗特征，我们报告了2020年1月1日至2020年2月28日通过核酸检测（NAT）确认为COVID-19的5名患者的病例系列。入院时最常见的症状是发热（5例患者，100%）、咳嗽（5例患者，100%）、肌痛或疲劳（3例患者，60%）和痰液生成（3例患者，60%）;血清肌酐或尿素氮水平略高于症状发作前。4例患者在住院期间接受了减少剂量的维持免疫抑制治疗。截至2020年3月4日，NAT连续两次在三名患者中对COVID-19呈阴性，他们的计算机断层扫描显示图像有所改善。虽然需要更多的患者数量和长期随访数据，但我们的系列研究表明，KTx接受者的轻度COVID-19感染可以通过对症支持治疗结合调整的维持免疫抑制治疗来管理。
Coronavirus disease 2019 (COVID-19) is a novel and lethal infectious disease, posing a threat to global health security. The number of cases has increased rapidly, but no data concerning kidney transplant (KTx) recipients infected with COVID-19 are available. To present the epidemiological, clinical, and therapeutic characteristics of KTx recipients infected with COVID-19, we report on a case series of five patients who were confirmed as having COVID-19 through nucleic acid testing (NAT) from January 1, 2020 to February 28, 2020. The most common symptoms on admission to hospital were fever (five patients, 100%), cough (five patients, 100%), myalgia or fatigue (three patients, 60%), and sputum production (three patients, 60%); serum creatinine or urea nitrogen levels were slightly higher than those before symptom onset. Four patients received a reduced dose of maintenance immunosuppressive therapy during hospitalization. As of March 4, 2020 NAT was negative for COVID-19 in three patients twice in succession, and their computed tomography scans showed improved images. Although greater patient numbers and long-term follow-up data are needed, our series demonstrates that mild COVID-19 infection in KTx recipients can be managed using symptomatic support therapy combined with adjusted maintenance immunosuppressive therapy.