High Spatial Resolution Digital Positron Emission Tomography Images With Dedicated Source-to-background Algorithm for Radiotherapy Planning
High Spatial Resolution Digital Positron Emission Tomography Images With Dedicated Source-to-background Algorithm for Radiotherapy Planning
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DOI：
10.21873/anticanres.14227
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发表时间：
2020-05-01
影响因子：
2
通讯作者：
Oya, Natsuo
中科院分区：
文献类型：
--
作者：
Watakabe, Takahiro;Toya, Ryo;Oya, Natsuo
背景/目的：评估高空间分辨率数字正电子发射断层扫描图像与源背景比（SBR）算法在大体肿瘤体积（GTV）描绘中的效用。材料和方法：碗和球体（10-37 毫米）充满氟-2-脱氧-D-葡萄糖，以实现 4-16 倍背景放射性。使用三种各向同性体素尺寸重建图像。计算了 SBR 和 SUVmax 的百分比阈值 (TH)。使用回归方程拟合 SBR 和 TH 之间的图。通过应用 TH 计算球体的轮廓体积 (CV)。结果：对于 4 mm 体素尺寸，TH 为 38.6+75.0/SBR； 2毫米为39.6+37.0/SBR； 1 毫米为 38.8+35.2/SBR。对于 4、2 和 1 mm 体素尺寸，CV 和真实体积之间的平均相对误差分别为 15%、7% 和 7%。结论：本技术对于 GTV 描绘很有用，可减少轮廓误差。
Background/Aim: To evaluate the utility of high spatial resolution digital positron emission tomography images with the source-to-background ratio (SBR) algorithm for gross tumour volume (GTV) delineation. Materials and Methods: The bowl and spheres (10-37 mm) were filled with fluoro-2-deoxy-D-glucose to achieve 4-16 times background radioactivity. The images were reconstructed using three isotropic voxel sizes. The SBR and percentage threshold (TH) to SUVmax were calculated. The plots between SBR and TH were fitted using a regression equation. The contoured volumes (CVs) of the spheres were calculated by applying TH. Results: TH was 38.6+75.0/SBR for 4 mm voxel size; 39.6+37.0/SBR for 2 mm; and 38.8+35.2/SBR for 1 mm. The mean relative errors between CV and true volume for 4, 2, and 1 mm voxel sizes were 15%, 7%, and 7%, respectively. Conclusion: The present technique is useful for GTV delineation with reduced contouring error.