Positron Emission Tomography Imaging of Dopamine D2/3 Receptors in the Human Cortex With [11C]FLB 457: Reproducibility Studies
Positron Emission Tomography Imaging of Dopamine D2/3 Receptors in the Human Cortex With [11C]FLB 457: Reproducibility Studies
复制标题
DOI：
10.1002/syn.20813
复制
发表时间：
2011-01-01
期刊：
影响因子：
2.3
通讯作者：
Frankle, W. Gordon
中科院分区：
文献类型：
--
作者：
Narendran, Rajesh;Mason, N. Scott;Frankle, W. Gordon
在最近的PET研究中，我们证明了用相对高亲和力的多巴胺D-2/3放射性配体[C-11]FLB 457测量安非他明诱导的人皮质中DA释放的能力（Narendran等人，[2009] Synapse 63：447-461）。本研究的目的是评价[C-11]FLB 457在我们用于测量苯丙胺诱导的DA传递的相同成像范例中的再现性和可靠性。用[C-11]FLB 457对6名健康人类受试者（3名男性/3名女性）进行了两次研究，一次在基线时，另一次在基线扫描结束后3小时。在感兴趣的皮质区域和小脑（参考区域）中使用双组织室动力学分析估计D-2/3受体结合参数。评估了[（11）C] FLB 457的分布容积（V-T）、相对于血浆浓度的结合潜力（BPP）和相对于不可置换摄取的结合潜力（BPND）的重测变异性和组内相关系数。[C-11]FLB 457 V-T、BPP和BPND的重测变异性为
In a recent PET study, we demonstrated the ability to measure amphetamine- induced DA release in the human cortex with the relatively high affinity dopamine D-2/3 radioligand [C-11]FLB 457 (Narendran et al., [2009] Synapse 63: 447-461). The aim of this study was to evaluate the reproducibility and reliability of [C-11]FLB 457 in the same imaging paradigm we used to measure amphetamine-induced DA transmission. Six healthy human subjects (three males/three females) were studied twice with [C-11]FLB 457, once at baseline and again 3 h following the end of the baseline scan. D-2/3 receptor binding parameters were estimated using a two-tissue compartment kinetic analysis in the cortical regions of interest and cerebellum (reference region). The test-retest variability and intraclass correlation coefficient were assessed for distribution volume (V-T), binding potential relative to plasma concentration (BPP), and binding potential relative to nondisplaceable uptake (BPND) of [(11) C] FLB 457. The test-retest variability of [C-11]FLB 457 V-T, BPP, and BPND were