Thoracic cage plasticity in prepubertal New Zealand white rabbits submitted to T1-T12 dorsal arthrodesis: computed tomography evaluation, echocardiographic assessment and cardio-pulmonary measurements
Thoracic cage plasticity in prepubertal New Zealand white rabbits submitted to T1-T12 dorsal arthrodesis: computed tomography evaluation, echocardiographic assessment and cardio-pulmonary measurements
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DOI：
10.1007/s00586-012-2644-x
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发表时间：
2013-05-01
影响因子：
2.8
通讯作者：
Cavalli, Fabio
中科院分区：
文献类型：
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作者：
Canavese, Federico;Dimeglio, Alain;Cavalli, Fabio
目的 我们的目的是描述新西兰白 (NZW) 青春期前兔子接受背关节固定术并在骨骼成熟时通过计算机断层扫描 (CT) 扫描观察到的胸廓和脊柱形态变化。这样做是为了通过突出脊柱关节融合术后的变化来评估脊柱未变形的兔子胸廓的可塑性。通过Emogas数据分析、超声心动图评估和心肺测量完成评估。方法对16只6周龄雌性兔进行手术。 9 例接受 T1-T12 背关节融合术，7 例进行假手术。手术涉及植入两根C形不锈钢棒和异种骨移植。术前、术后2、6和12个月进行CT扫描。最后一次 CT 扫描后一周，进行超声心动图和 emogas 评估。 结果 与假手术兔相比，手术兔的胸部深度 (8 %)、胸椎后凸 (ThK) (23 %)、胸椎背侧和腹侧长度 (11 %) 和胸骨长度 (7 %) 显着减少。 PaCO2、PaO2 和 sO(2) 的平均值+/-标准差（SD）没有显着差异。除收缩期室间隔厚度、左心室收缩能力和射血分数外，两组兔超声心动图测量的平均值+/-SD均无显着差异。结论青春期前NZW兔脊柱未变形的T1-T12背关节融合术引起胸廓形态的变化。然而，这些变化是心肺并发症的根源，其严重程度不足以重现与人类胸廓供血不足综合征相当的临床表现。
Purpose We aimed to describe the morphological changes in the thoracic cage and spinal column induced in New Zealand White (NZW) prepubertal rabbits subjected to dorsal arthrodesis and observed at skeletal maturity by computed tomography (CT) scans. This was done to evaluate the plasticity of the thoracic cage of rabbits with non-deformed spine, by highlighting its modifications after spinal arthrodesis. Emogas data analysis, echocardiographic assessment and cardio-pulmonary measurements completed the evaluation.Methods Surgery was performed in 16 female rabbits, 6 weeks old. Nine were subjected to T1-T12 dorsal arthrodesis, while seven were sham-operated. Surgery involved the implant of two C-shaped stainless steel bars and heterologous bone graft. CT scans were performed before surgery, 2, 6 and 12 months after surgery. One week after the last CT scan, echocardiographic and emogas evaluations were performed.Results Chest depth (8 %), thoracic kyphosis (ThK) (23 %), dorsal and ventral length of the thoracic spine (11 %) and sternal length (7 %) were significantly reduced in operated compared to sham-operated rabbits. Mean values +/- standard deviation (SD) of PaCO2, PaO2 and sO(2) were not significantly different. Mean values +/- SD of echocardiographic measurements were not significantly different between the two groups of rabbits, except for thickness of the interventricular septum in systole, contractile capacity of the left ventricle and ejection fraction.Conclusions T1-T12 dorsal arthrodesis in prepubertal NZW rabbits with non-deformed spine induced changes of the thoracic cage morphology. However, those changes are source of cardio-pulmonary complications not severe enough to reproduce a clinical picture comparable to thoracic insufficiency syndrome in humans.