Hyperbaric Oxygen Exposure Improves Blood Glucose Level and Muscle Oxidative Capacity in Rats with Type 2 Diabetes
Hyperbaric Oxygen Exposure Improves Blood Glucose Level and Muscle Oxidative Capacity in Rats with Type 2 Diabetes
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DOI：
10.1089/dia.2009.0104
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发表时间：
2010-02-01
影响因子：
5.4
通讯作者：
Ishihara, Akihiko
中科院分区：
文献类型：
--
作者：
Gu, Ning;Nagatomo, Fumiko;Ishihara, Akihiko
背景：研究了高压氧暴露对2型糖尿病大鼠血糖水平和肌肉氧化能力的影响。方法:有没有男性Goto-Kakizaki老鼠分为四组:normobaric (NN,暴露于8周21%的氧气在760毫米汞柱),高压,normobaric (HN;暴露4周36%的氧气在950毫米汞柱,其次是21%的氧气在760毫米汞柱4周),normobaric到高压(NH;暴露4周21%的氧气在760毫米汞柱,其次是36%的氧气在950毫米汞柱4周),和高压(HH,暴露于8周36%的氧气在950毫米汞柱)。结果：HN、NH、HH组血糖水平均低于NN组。在HN、NH和HH组的比目鱼肌以及HN和HH组的足底肌中，过氧化物酶体增殖体激活受体- γ共激活因子-1 α mRNA表达水平上调。NN组的比目鱼肌只含有I型纤维，而HN、NH和HH组的比目鱼肌含有I型、IIA型和IIC型纤维。在NH、HN和HH组足底肌肉中，I型纤维百分比增加，IIB型纤维百分比减少。结论：暴露于高压氧可降低糖尿病大鼠的高血糖水平，提高骨骼肌的氧化能力，这些作用即使在暴露于高压氧后也能在常压条件下保持。
Background: The effects of exposure to hyperbaric oxygen on blood glucose level and muscle oxidative capacity in rats with type 2 diabetes were investigated.Methods: Five-week-old male Goto-Kakizaki rats were divided into four groups: normobaric (NN; exposed to 21% oxygen at 760 mm Hg for 8 weeks), hyperbaric to normobaric (HN; exposed to 36% oxygen at 950 mm Hg for 4 weeks, followed by 21% oxygen at 760 mm Hg for 4 weeks), normobaric to hyperbaric (NH; exposed to 21% oxygen at 760 mm Hg for 4 weeks, followed by 36% oxygen at 950 mm Hg for 4 weeks), and hyperbaric (HH; exposed to 36% oxygen at 950 mm Hg for 8 weeks).Results: Blood glucose levels were lower in the HN, NH, and HH groups than in the NN group. Up-regulated mRNA expression levels of peroxisome proliferator-activated receptor-gamma co-activator-1 alpha were observed in the soleus muscles of the HN, NH, and HH groups and in the plantaris muscles of the HN and HH groups. The soleus muscles of the NN group contained only type I fibers, whereas those of the HN, NH, and HH groups contained type I, type IIA, and type IIC fibers. An increased percentage of type I fibers and a decreased percentage of type IIB fibers were observed in the plantaris muscles of the NH, HN, and HH groups.Conclusions: Exposure to hyperbaric oxygen reduces high blood glucose levels and improves oxidative capacities in the skeletal muscles of rats with diabetes, and these effects are maintained under normobaric conditions even after exposure to hyperbaric oxygen.