ORAL VACCINATION OF THE FOX AGAINST RABIES USING A LIVE RECOMBINANT VACCINIA VIRUS
ORAL VACCINATION OF THE FOX AGAINST RABIES USING A LIVE RECOMBINANT VACCINIA VIRUS
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DOI：
10.1038/322373a0
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发表时间：
1986-07-24
期刊：
影响因子：
64.8
通讯作者：
DESMETTRE, P
中科院分区：
文献类型：
--
作者：
BLANCOU, J;KIENY, MP;DESMETTRE, P
狂犬病是一种影响所有温血动物的病毒性疾病，在世界大部分地区流行1，在野生动物中传播，特别是狐狸和狗。人和牲畜感染的公共卫生和经济后果是众所周知的。通过给野生食肉动物接种灭活或减毒的狂犬病病毒来控制疾病的尝试仍然存在争议，我们在这里评估了重组牛痘病毒保护狐狸免受疾病侵害的潜力。我们已经发现，接种牛痘病毒（VV）或携带狂犬病表面抗原基因（VVTGgRAB）的重组体对狐狸无害。重组病毒可诱导产生相当于或上级狂犬病中和抗体滴度的狂犬病中和抗体，皮下、皮内或口服108空斑形成单位（PFU）的VVTGIgRAB可完全保护狂犬病病毒的严重攻击感染。
Rabies, a viral disease affecting all warm-blooded animals, is prevalent in most parts of the world1, where it propagates amongst wild animals, particularly the fox and dog. The public health and economic consequences of infection in man and livestock are well known. Attempts to control the disease by vaccinating wild carnivores with inactivated or attenuated rabies virus remain controversial, and we have instead evaluated here the potential of a recombinant vaccinia virus to protect foxes against the disease. We have found that the administration of vaccinia virus (VV) or a recombinant harbouring the rabies surface antigen gene (VVTGgRAB) is innocuous to foxes. The recombinant virus can elicit the production of titres of rabies-neutralizing antibodies equal or superior to those obtained with conventional vaccine, and 108plaque-forming units (PFU) of VVTGIgRAB administered subcutaneously, intradermally or orally confers complete protection to severe challenge infection with street rabies virus.