A mosquito lipoxin/lipocalin complex mediates innate immune priming in Anopheles gambiae.
A mosquito lipoxin/lipocalin complex mediates innate immune priming in Anopheles gambiae.
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DOI：
10.1038/ncomms8403
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发表时间：
2015-06-23
影响因子：
16.6
通讯作者：
Barillas-Mury C
中科院分区：
文献类型：
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作者：
Ramirez JL;de Almeida Oliveira G;Calvo E;Dalli J;Colas RA;Serhan CN;Ribeiro JM;Barillas-Mury C
Exposure of Anopheles gambiae mosquitoes to Plasmodium infection enhances the ability of their immune system to respond to subsequent infections. However, the molecular mechanism that allows the insect innate immune system to ‘remember' a previous encounter with a pathogen has not been established. Challenged mosquitoes constitutively release a soluble haemocyte differentiation factor into their haemolymph that, when transferred into Naive mosquitoes, also induces priming. Here we show that this factor consists of a Lipoxin/Lipocalin complex. We demonstrate that innate immune priming in mosquitoes involves a persistent increase in expression of Evokin (a lipid carrier of the lipocalin family), and in their ability to convert arachidonic acid to lipoxins, predominantly Lipoxin A4. Plasmodium ookinete midgut invasion triggers immune priming by inducing the release of a mosquito lipoxin/lipocalin complex. A soluble factor induced by Plasmodium infection promotes hemocyte differentiation and increases mosquitoe resistance to subsequent infections. Here the authors show that this factor consists of a Lipocalin/Lipoxin A4 complex, and that insects can metabolize arachidonic acid to produce lipoxins.
