Effective synthesis of C-nucleosides with 2′,4′-BNA modification
Effective synthesis of C-nucleosides with 2′,4′-BNA modification
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DOI：
10.1016/s0040-4020(02)00226-0
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发表时间：
2002-04-08
期刊：
影响因子：
2.1
通讯作者：
Imanishia, T
中科院分区：
文献类型：
--
作者：
Hari, Y;Obika, S;Imanishia, T
利用四氢呋喃甲醛1与芳香杂环的镁或锂衍生物的偶联反应，再经Mitsunobu环化反应，有效地合成了一些2 ′-O，4 ′-C-亚甲基桥核酸（2 ′，4 ′-BNA）修饰的C-核苷。此外，它是由H-1 NMR谱和X-射线晶体学清楚地表明，在合成的C-核苷糖构象，独立于核碱基，固定在N-型。(C)2002爱思唯尔科技有限公司版权所有。
The effective synthesis of some C-nucleosides with 2'-O,4'-C-methylene bridged nucleic acid (2',4'-BNA) modification was accomplished by using the coupling reaction of a tetrahydrofurancarbaldehyde 1 with the magnesium or lithium derivatives of aromatic heterocycles followed by the Mitsunobu cyclization. Moreover, it was clearly shown by H-1 NMR spectra and X-ray crystallography that the sugar conformation in the synthesized C-nucleosides, independent of the nucleobases, was fixed in N-form. (C) 2002 Elsevier Science Ltd. All rights reserved.