Malignant ossifying fibromyxoid tumor of the tongue: case report and review of the literature.
Malignant ossifying fibromyxoid tumor of the tongue: case report and review of the literature.
复制标题
DOI：
10.1186/1746-160x-9-16
复制
发表时间：
2013-06-24
影响因子：
3
通讯作者：
Kamata N
中科院分区：
文献类型：
--
作者：
Ohta K;Taki M;Ogawa I;Ono S;Mizuta K;Fujimoto S;Takata T;Kamata N
骨化性纤维粘液样肿瘤(OFMT)是一种罕见的间叶性肿瘤，发生在皮下组织中，在口腔中极为罕见。我们提出一例舌癌的病例。一名26岁的男性注意到舌头上有一个无痛肿块，这是在一家综合医院提取的。四年后，肿瘤复发，在我科接受了手术切除。组织学上，复发肿瘤由紧密堆积的波形蛋白阳性细胞和S-100细胞组成，呈结节状增殖。具有较高的细胞密度和有丝分裂活性。在原发肿瘤中，一些肿瘤细胞以弥漫性或索状排列在丰富的纤维粘液基质中，并伴有少量的化生骨化，符合OFMT的组织病理学特征。因此，诊断出发生在典型的OFMT中的恶性OFMT。这是首例报告的舌部恶性OFMT病例。需要长期随访以确认预后和生物学行为。
Ossifying fibromyxoid tumor (OFMT) is a rare mesenchymal neoplasm that arises in subcutaneous tissue, with that in the oral cavity extremely rare. We present a case of malignant OFMT in the tongue. A 26-year-old male noticed a painless mass in the tongue, which was extracted at a general hospital. Four years later, the tumor recurred and was resected at our department. Histologically, the recurrent tumor was composed of the closely packed cells positive for vimentin and S-100 proliferating in a nodular fashion. It showed high cellularity and mitotic activity. In the primary tumor, some tumor cells were arranged in a diffuse or cord-like manner within an abundant fibromyxoid matrix, along with a small amount of metaplastic ossification, corresponding with the histopathological characteristic of OFMT. Accordingly, a diagnosis of malignant OFMT arising in typical OFMT was established. This is the first reported case of malignant OFMT in the tongue. Long-term follow-up is needed for confirmation of prognosis and biological behavior.