Chronic Diseases, Chromosomal Abnormalities, and Congenital Malformations as Risk Factors for Respiratory Syncytial Virus Hospitalization: A Population-Based Cohort Study
Chronic Diseases, Chromosomal Abnormalities, and Congenital Malformations as Risk Factors for Respiratory Syncytial Virus Hospitalization: A Population-Based Cohort Study
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DOI：
10.1093/cid/cir928
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发表时间：
2012-03-15
影响因子：
11.8
通讯作者：
Stensballe, Lone G.
中科院分区：
文献类型：
--
作者：
Kristensen, Kim;Hjuler, Thomas;Stensballe, Lone G.
背景除了早产、心脏病和唐氏综合征之外，其他慢性疾病如何影响呼吸道合胞病毒（RSV）住院的风险和严重程度，目前还知之甚少。我们在这项基于登记的、基于人群的队列研究中评估了慢性疾病儿童RSV住院的风险和严重程度。从丹麦RSV数据库、国家患者和出生登记处以及民事登记系统中获得了RSV检测、母亲吸烟、兄弟姐妹、单亲、分娩方式、出生时胎龄、大手术、哮喘诊断、慢性疾病以及住院和出院日期的数据。使用考克斯回归模型估计按性别和出生日期分层的组间RSV住院的发生率比（IRR）。采用线性回归分析RSV住院时间，并报告为几何平均值比率。共有391983名0-23个月的儿童被纳入分析。共有10 616人（2.7%）被诊断为慢性病。患有任何先天性或获得性慢性病的儿童因RSV住院的IRR（95%置信区间）分别为2.18（2.01-2.36）和2.25（1.94-2.61）。确定了RSV住院治疗的几个新风险因素，包括畸形、间质性肺病、神经肌肉疾病、肝病、染色体异常、先天性免疫缺陷和先天性代谢缺陷。在许多慢性疾病中，RSV住院时间增加。慢性疾病本身是RSV住院的重要风险因素。
Background. Little is known about how chronic conditions other than prematurity, heart disease, and Down syndrome affect the risk and severity of hospitalization for respiratory syncytial virus (RSV). We assess the risk and severity of RSV hospitalization in children with chronic conditions in this register-based, population-based cohort study.Methods. Data on RSV tests, maternal smoking, siblings, single parenthood, mode of delivery, gestational age at birth, major surgery, asthma diagnosis, chronic conditions, and hospitalization and discharge dates were obtained from the Danish RSV database, the National Patient and Birth Registries, and the Civil Registration System.Statistics. Cox regression models were used to estimate incidence rate ratios (IRRs) for RSV hospitalization between groups stratified by sex and date of birth. Duration of RSV hospitalization was analyzed in a linear regression and reported as geometric mean ratios.Results. A total of 391 983 children aged 0-23 months were included in the analysis. A total of 10 616 (2.7%) had a diagnosis for chronic disease. IRRs (95% confidence intervals) for RSV hospitalization in children with any congenital or acquired chronic condition were 2.18 (2.01-2.36) and 2.25 (1.94-2.61), respectively. Several new risk factors for RSV hospitalization, including malformations, interstitial lung disease, neuromuscular disease, liver disease, chromosomal abnormalities, congenital immunodeficiencies, and inborn errors of metabolism, were identified. Duration of RSV hospitalization was increased in many chronic conditions.Conclusions. Chronic disease per se is an important risk factor for RSV hospitalization.