Cytomegalovirus viral and antibody correlates in young children.
Cytomegalovirus viral and antibody correlates in young children.
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DOI：
10.1186/1756-0500-7-776
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发表时间：
2014-11-03
影响因子：
1.8
通讯作者：
Hyde TB
中科院分区：
文献类型：
--
作者：
Dollard SC;Keyserling H;Radford K;Amin MM;Stowell J;Winter J;Schmid DS;Cannon MJ;Hyde TB
年轻健康的儿童在尿液和唾液中脱落巨细胞病毒（CMV）似乎是孕妇原发感染CMV的主要来源。我们对48名6个月至5岁的儿童进行了CMV IgG筛查，并测量了CMV IgG、IgM和IgG亲合力抗体水平、CMV脱落频率以及血液、尿液和唾液中的病毒载量。48例患儿中13例（27%）CMV IgG阳性，其中3例CMV IgM阳性，有近期原发感染的证据。13名血清反应阳性儿童中有9名（69%）在一种或多种体液中脱落102-105拷贝/ml的CMV DNA。在血清学阳性儿童中，IgG抗体滴度低（1：20-1：80）与无脱落相关（p = 0.014），日托与CMV脱落相关（p = 0.037）。CMV抗体谱与CMV脱落相关。CMV IgM的存在更常代表儿童的原发性感染。将抗体与健康儿童的原发感染和病毒脱落相关，增加了对儿童CMV感染的理解，可以为预防孕妇CMV传播提供信息。
Young, healthy children shedding cytomegalovirus (CMV) in urine and saliva appear to be the leading source of CMV in primary infection of pregnant women. We screened 48 children 6 months – 5 years old for CMV IgG and measured levels of CMV IgG, IgM and IgG avidity antibodies, frequency of CMV shedding, and viral loads in blood, urine, and saliva. Thirteen of the 48 children (27%) were CMV IgG positive, among whom 3 were also CMV IgM positive with evidence of recent primary infection. Nine of the 13 seropositive children (69%) were shedding 102-105 copies/ml of CMV DNA in one or more bodily fluid. Among seropositive children, low IgG antibody titer (1:20–1:80) was associated with the absence of shedding (p = 0.014), and enrollment in daycare was associated with the presence of CMV shedding (p = 0.037). CMV antibody profiles correlated with CMV shedding. The presence of CMV IgM more often represents primary infection in children than in adults. Correlating antibodies with primary infection and viral shedding in healthy children adds to the understanding of CMV infection in children that can inform the prevention of CMV transmission to pregnant women.