Integrin-mediated short-term memory in Drosophila
Integrin-mediated short-term memory in Drosophila
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DOI：
10.1038/35079
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发表时间：
1998-01-29
期刊：
影响因子：
64.8
通讯作者：
Davis, RL
中科院分区：
文献类型：
--
作者：
Grotewiel, MS;Beck, CDO;Davis, RL
Volado是果蝇的一种新的记忆突变体。该基因座编码一种新的α-整合素的两种异构体，一种动态调节细胞黏附和信号转导的分子。Volado基因在蘑菇体细胞中优先表达，蘑菇体细胞是已知的介导昆虫嗅觉学习的神经元。Volado蛋白集中在蘑菇体神经枕中，这是包含与其他神经元突触接触的蘑菇体突起的大脑区域。Volado突变体在训练后3分钟内显示出嗅觉记忆受损，这表明整合素是短期记忆过程所必需的。成年期间有条件地表达一种Volado转基因可以挽救记忆障碍。这种记忆的挽救是可逆的，随着转基因的表达而逐渐褪色。因此，Volado整合素对于记忆底层的生理过程是必不可少的。我们提出了一个模型，在这个模型中，整合素作为突触结构或短期记忆形成背后的信号事件的动态调节器。
Volado is a new memory mutant of Drosophila. the locus encodes two isoforms of a new a-integrin, a molecule that dynamically mediates cell adhesion and signal transduction. The Volado gene is expressed preferentially in mushroom body cells, which are neurons known to mediate olfactory learning in insects. Volado proteins are concentrated in the mushroom body neuropil, brain areas that contain mushroom body processes in synaptic contact with other neurons. Volado mutants display impaired olfactory memories within 3 min of training, indicating that the integrin is required for short-term memory processes. Conditional expression of a Volado transgene during adulthood rescues the memory impairment. This rescue of memory is reversible, fading over time along with expression of the transgene. Thus the Volado integrin is essential for the physiological processes underlying memory. We propose a model in which integrins act as dynamic regulators of synapse structure or the signalling events underlying short-term memory formation.