PEGylated CsxWO3 nanorods as an efficient and stable 915 nm-laser-driven photothermal agent against cancer cells
PEGylated CsxWO3 nanorods as an efficient and stable 915 nm-laser-driven photothermal agent against cancer cells
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聚乙二醇化 CsxWO3 纳米棒作为有效且稳定的 915 nm 激光驱动光热剂对抗癌细胞
DOI：
10.1039/c4ra15524f
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发表时间：
2015-01-01
期刊：
影响因子：
3.9
通讯作者：
Zhu, Meifang
中科院分区：
文献类型：
--
作者：
Xu, Wenju;Meng, Zhouqi;Zhu, Meifang
WO 3-x纳米材料是一种高效的近红外激光驱动的光热纳米材料，但其光热稳定性尚不令人满意。此外，通常使用980 nm激光作为NIR光源，但由于水和生物标本的光学吸收，它具有过热效应。为了解决这些问题，我们通过溶剂热合成-聚乙二醇化两步法制备了聚乙二醇化铯掺杂的WO 3（CsxWO 3）纳米棒。CsxWO 3纳米棒具有类似于11 nm的直径和类似于50 nm的长度，并且它们在NIR区域（700-1100 nm）中表现出增加的吸收。以聚乙二醇化的CsxWO 3纳米棒作为光热纳米剂，我们比较了915和980 nm激光作为近红外光源的过热和穿透效应。与980 nm激光相比，915 nm激光对水的过热程度大大降低，而且由于吸水率非常低，因此水/皮肤的渗透能力更高。重要的是，在915 nm激光的照射下，CsxWO 3纳米棒表现出优异的光热转换性能和高稳定性。此外，通过PEG化CsxWO 3纳米棒的光热效应，在915 nm激光的照射下，可以有效地破坏体内癌细胞。因此，聚乙二醇化CsxWO 3纳米棒可以作为一个有前途的高效和稳定的近红外激光驱动的光热剂对体内癌细胞。
WO3-x nanomaterials have been demonstrated to be one kind of efficient near-infrared (NIR) laser-driven photothermal nanoagents, but their photothermal stability is still unsatisfied. In addition, a 980 nm laser is usually used as NIR light source, but it has an overheating effect due to optical absorption of water and biological specimens. To address these problems, we have prepared PEGylated Cs-doped WO3 (CsxWO3) nanorods by a solvothermal synthesis-PEGylation two-step route. CsxWO3 nanorods have diameters of similar to 11 nm and lengths of similar to 50 nm, and they exhibit increased absorption in the NIR region (700-1100 nm). With PEGylated CsxWO3 nanorods as the photothermal nanoagent, we compare the overheating and penetration effects of 915 and 980 nm lasers as NIR light sources. Compared with the 980 nm laser, the 915 nm laser provides drastically less overheating of water, and higher penetration ability of water/skin due to quite low water absorption. Importantly, under the irradiation of a 915 nm laser, CsxWO3 nanorods exhibit excellent photothermal conversion performance with high stability. Furthermore, by the photothermal effect of PEGylated CsxWO3 nanorods, in vivo cancer cells can be efficiently destroyed under the irradiation of a 915 nm laser. Therefore, PEGylated CsxWO3 nanorods can be used as a promising efficient and stable NIR-laser-driven photothermal agent against in vivo cancer cells.