Riboswitch RNAs: regulation of gene expression by direct monitoring of a physiological signal.
Riboswitch RNAs: regulation of gene expression by direct monitoring of a physiological signal.
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DOI：
10.4161/rna.7.1.10757
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发表时间：
2010-01
期刊：
影响因子：
4.1
通讯作者：
Henkin TM
中科院分区：
文献类型：
--
作者：
Smith AM;Fuchs RT;Grundy FJ;Henkin TM
核糖开关是顺式编码、顺式作用的RNA元件，直接感知生理信号。信号反应导致RNA结构的改变，从而影响基因表达。这种类型的元素在细菌中发挥重要作用，它们调节各种基本的细胞途径。核糖体开关介导的基因调控最常发生在转录衰减上，控制是否合成全长转录物，或翻译起始上，在这种情况下，转录物是组成性合成的，但翻译起始复合物的结合受到调节。将概述核糖开关rna在细菌基因表达中的作用，并更详细地描述几个例子，以说明已发现的机制类型。
Riboswitches are cis-encoded, cis-acting RNA elements that directly sense a physiological signal. Signal response results in a change in RNA structure that impacts gene expression. Elements of this type play an important role in bacteria, where they regulate a variety of fundamental cellular pathways. Riboswitch-mediated gene regulation most commonly occurs by effects on transcription attenuation, to control whether a full-length transcript is synthesized, or on translation initiation, in which case the transcript is constitutively synthesized but binding of the translation initiation complex is modulated. An overview of the role of riboswitch RNAs in bacterial gene expression will be provided, and a few examples are described in more detail to illustrate the types of mechanisms that have been uncovered.