MONOTONE SMOOTHING WITH APPLICATION TO DOSE-RESPONSE CURVES AND THE ASSESSMENT OF SYNERGISM
MONOTONE SMOOTHING WITH APPLICATION TO DOSE-RESPONSE CURVES AND THE ASSESSMENT OF SYNERGISM
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DOI：
10.2307/2532449
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发表时间：
1990-12-01
期刊：
影响因子：
1.9
通讯作者：
RICE, J
中科院分区：
文献类型：
--
作者：
KELLY, C;RICE, J
提出了一种基于样条函数的单调曲线平滑程序，并通过应用于剂量反应曲线来说明。然后，它示出了如何平滑可以应用于评估可能的协同作用或拮抗作用的两种药物。
A spline-based procedure for monotone curve smoothing is proposed and is illustrated by application to dose-response curves. It is then shown how such smoothing can be applied to assess possible synergism or antagonism of two drugs.