Bipolar disorder in adult patients with Tourette's syndrome: A clinical study
Bipolar disorder in adult patients with Tourette's syndrome: A clinical study
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DOI：
10.1016/s0006-3223(97)00025-5
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发表时间：
1998-03-01
影响因子：
10.6
通讯作者：
Campos, VM
中科院分区：
文献类型：
--
作者：
Berthier, ML;Kulisevsky, J;Campos, VM
背景：尽管最近的临床和流行病学研究表明，妥瑞特综合征（TS）与双相情感障碍（BPD）的发生率高于预期，但TS患者的BPD临床特征尚未得到广泛研究。方法：从连续90例转诊的TS患者中选择30例合并BPD的成年TS患者，采用结构化精神病学评定量表进行检查。结果：发现了BPD的完整临床谱，包括双相I型障碍、分裂情感性双相障碍、双相II型障碍和循环胸腺障碍。非典型植物性抑郁症状、快速循环模式和季节性复发模式也有记录。在目前的临床样本中，BPD主要发生在轻度抽动症状的患者中，并且始终与广泛性焦虑障碍、强迫症、恐慌、恐惧症、饮食障碍、自残行为、注意缺陷多动障碍、冲动控制障碍和人格障碍等一般精神病理的高终生患病率相关。结论：这项临床研究的结果表明，BPD和非情感性精神病理可能是TS患者亚群中突出的共病障碍。
Background: Although recent clinical and epidemiological studies indicate that Tourette's syndrome (TS) is associated with a higher than expected rate of bipolar disorder (BPD), the clinical characteristics of BPD in patients with TS have not been widely investigated.Methods: Thirty adult TS patients with comorbid BPD were selected from a consecutive series of 90 referred TS patients and examined using structured psychiatric rating scales.Results: The full clinical spectrum of BPD was found, including bipolar I disorder, schizoaffective bipolar disorder, bipolar II disorder, and cyclothymic disorder. Atypical vegetative depressive symptoms, rapid cycling patterns, and seasonal patterns of recurrence were also documented. In the present clinical sample, BPD mainly occurred in patients with mild tic symptoms and was invariably associated with a high lifetime prevalence of general psychopathology, including generalized anxiety disorder, obsessive-compulsive disorder, panic, phobias, eating disorders, self-injurious behavior, attention-deficit hyperactivity disorder, impulse control disorders, and personality disorders.Conclusions: The results of this clinical study indicate that BPD and nonaffective psychopathology may be prominent comorbid disorders in a subpopulation of patients with TS. (C) 1998 Society of Biological Psychiatry.