Adrenal medullary catecholamine secretion patterns in rats evoked by reflex and direct neural stimulation.
Adrenal medullary catecholamine secretion patterns in rats evoked by reflex and direct neural stimulation.
复制标题
由反射和直接神经刺激引起的大鼠肾上腺髓质儿茶酚胺分泌模式。
DOI：
10.1081/ceh-100102002
复制
发表时间：
2000
期刊：
影响因子：
--
通讯作者：
Edwards,DJ
中科院分区：
文献类型：
--
作者：
Vollmer,RR;Balcita-Pedicino,JJ;Debnam,AJ;Edwards,DJ
在戊巴比妥麻醉的雄性Sprague-Dawley大鼠上，测定肾上腺髓质的肾上腺素（EPI）和去甲肾上腺素（NE）、反射（低血压和低血糖）和直接神经刺激诱发的分泌模式。通过收集肾上腺静脉血测定分泌率。在神经支配和去神经支配的腺体中，基线儿茶酚胺分泌是相似的，这表明几乎没有对髓质的紧张性交感神经驱动。肼苯哒嗪诱导的低血压和胰岛素诱导的低血糖均显著增加儿茶酚胺的分泌，其中EPI的分泌占主导地位。同样，在内脏神经的刺激，EPI和NE的频率相关的增量引起的EPI释放大于NE在所有频率。然而，在内脏刺激在1赫兹以上的频率大大超过了反射刺激所实现的释放分泌增加的幅度。结果表明，尽管低血压和低血糖的刺激是由大脑中不同的中枢整合的，但肾上腺释放的模式是相似的。
Epinephrine (EPI) and norepinephrine (NE), secretion patterns evoked by reflex (to hypotension and hypoglycemia) and direct neural stimulation of the adrenal medulla were measured in pentobarbital anesthetized male Sprague-Dawley rats. Secretion rates were determined by collecting adrenal venous blood. Baseline catecholamine secretion was similar in innervated and denervated glands indicating that there was little tonic sympathetic neural drive to the medulla. Both hydralazine-induced hypotension and insulin-induced hypoglycemia significantly increased catecholamine secretion with the secretion of EPI predominating. Similarly, in response to stimulation of the splanchnic nerve, frequency-related increments in EPI and NE were elicited with EPI release being greater than NE at all frequencies. However, the magnitude of the increase in secretion during splanchnic stimulation at frequencies above 1 hz greatly exceeded the release achieved by reflex stimulation. The results indicate that despite the fact that the stimuli of hypotension and hypoglycemia are integrated by different centers in the brain, the pattern of adrenal release is similar.