Contralateral treatment with xylocaine reduces nociceptive behaviour in mononeuropathic rats
Contralateral treatment with xylocaine reduces nociceptive behaviour in mononeuropathic rats
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DOI：
10.1097/00001756-200002070-00014
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发表时间：
2000-02
期刊：
影响因子：
1.7
通讯作者：
I. Bileviciute-Ljungar;T. Lundeberg
中科院分区：
文献类型：
--
作者：
I. Bileviciute-Ljungar;T. Lundeberg
The aim of the present study was to establish whether contralateral treatment with local anaesthetics reduces nociceptive behaviour in mononeuropathic rats. Contralateral treatment with xylocaine on day 6 and 11 following sciatic nerve ligation increased withdrawal latencies to thermal but not to mechanical stimulation for 3–4 days. Rats who received contralateral treatment with xylocaine on day 6 and 11 showed a reduced autotomy score during the following 6 weeks. To compare ipsilateral and contralateral effects another set of experiments was performed. Rats treated contralaterally on day 11 had a significantly lower autotomy score at week 4 and 6. Our results demonstrate that contralateral treatment with xylocaine reduces nociceptive behaviour in mononeuropathic rats for days or weeks.
