The organic anion transporter (OATP) family.
The organic anion transporter (OATP) family.
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DOI：
10.2133/dmpk.19.171
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发表时间：
2004-06-01
影响因子：
2.1
通讯作者：
Abe, Takaaki
中科院分区：
文献类型：
--
作者：
Mikkaichi, Tsuyoshi;Suzuki, Takehiro;Abe, Takaaki
在过去的十年中，许多有机阴离子转运蛋白被分离出来，并对其分布和底物进行了研究。最近鉴定的有机阴离子转运蛋白家族OATP（有机阴离子转运多肽）/LST（肝脏特异性转运蛋白）家族，转运胆汁酸、激素以及类花生酸、各种化合物（BSP、HMG-CoA还原酶抑制剂、血管紧张素转化酶抑制剂等）。该家族的分离揭示了不仅亲水性化合物，亲脂性药物和激素都需要膜转运系统才能穿透细胞膜。在这个家庭，命名变得非常复杂，这个家庭的生理作用仍然不清楚，除了一些器官，如脑，肝和肾。即使在这样的器官中，OATP/LST家族的共存和相似的底物特异性阻碍了识别转运蛋白家族的真实的作用的进展和明确表征。在这里，最近的进展和洞察力，这一领域的审查。
In the last decade, many organic anion transporters have been isolated, characterized their distribution and substrates. The recently identified organic anion transporter family OATP (organic anion transporting polypeptide)/LST (liver-specific transporter) family, transport bile acids, hormones as well as eicosanoids, various compounds (BSP, HMG-CoA reductase inhibitor, angiotensin converting enzyme inhibitor, etc.). The isolation of the family revealed that not only hydrophilic compounds, drugs and hormones of lipophilic nature need a membrane transport system to penetrate cell membrane. In this family, the nomenclature becomes very complicated and the physiological role of this family is still unclear except about few organs such as the brain, liver and kidney. Even in such organs, the co-existence of the OATP/LST family and similar substrate specificity hamper the progress and clear characterization identifying the real role of the transporter family. Here, recent progress and an insight of this field are reviewed.