A 'time bomb' in the human intestine-the multiple emergence and spread of antibiotic-resistant bacteria
A 'time bomb' in the human intestine-the multiple emergence and spread of antibiotic-resistant bacteria
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人体肠道的“定时炸弹”——耐药菌的多重出现和扩散
DOI：
10.1111/1462-2920.15795
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发表时间：
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影响因子：
5.1
通讯作者：
He Jin
中科院分区：
文献类型：
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作者：
Zhang Yuling;Xu Siyang;Yang Yijun;Chou Shan-Ho;He Jin
抗生素对细菌有很强的杀灭作用，是预防和治疗细菌感染性疾病的首选药物。因此，它们已被广泛应用于医疗领域，畜牧业和种植业。然而，随着抗生素的大量使用，出现了越来越多的抗生素耐药菌（ARB）。由于人体肠道营养丰富，温度适宜，细菌丰度高，很容易成为ARB和抗生素耐药基因（ARG）传播的温床。当肠道内的条件致病菌获得ARG后，由这些条件致病菌引起的感染性疾病将变得更加难以治疗，甚至无法治愈。因此，ARB在人体肠道中就像一颗“定时炸弹”。本文从One Health的角度对肠道ARB的来源及ARG在人体肠道的传播途径进行了综述。此外，我们描述了各种方法来防止ARB的出现和抑制ARG在人体肠道中的传播。最后，我们可能能够使用跨学科的“同一健康”方法克服人类肠道中的ARB。
Antibiotics have a strong killing effect on bacteria and are the first choice for the prevention and treatment of bacterial infectious diseases. Therefore, they have been widely used in the medical field, animal husbandry and planting industry. However, with the massive use of antibiotics, more and more antibiotic‐resistant bacteria (ARB) have emerged. Because human intestines are rich in nutrients, have suitable temperature, and are high in bacterial abundance, they can easily become a hotbed for the spread of ARB and antibiotic‐resistant genes (ARGs). When opportunistic pathogenic bacteria in the intestine acquire ARGs, the infectious diseases caused by such opportunistic pathogens will become more difficult to treat, or even impossible to cure. Therefore, ARB in the human intestine are like a ‘time bomb’. In this review, we discuss the sources of intestinal ARB and the transmission routes of ARGs in the human intestine from the perspective of One Health. Further, we describe various methods to prevent the emergence of ARB and inhibit the spread of ARGs in the human intestine. Finally, we may be able to overcome ARB in the human intestine using an interdisciplinary ‘One Health’ approach.