SINGLE UNIT ANALYSIS OF MECHANORECEPTOR ACTIVITY FROM HUMAN GLABROUS SKIN
SINGLE UNIT ANALYSIS OF MECHANORECEPTOR ACTIVITY FROM HUMAN GLABROUS SKIN
复制标题
DOI：
10.1111/j.1748-1716.1970.tb04783.x
复制
发表时间：
1970-01-01
期刊：
影响因子：
--
通讯作者：
VALLBO, AB
中科院分区：
文献类型：
--
作者：
KNIBESTOL, M;VALLBO, AB
在清醒的人受试者的正中神经和尺神经上，用经皮插入的钨电极记录单个单位脉冲。本文分析了无毛皮肤中61个机械感受器单位的感受野特征及其末梢的基本生理特性。可区分出4种不同类型的受体。这种区别主要基于适应和感受野特征，尽管也观察到其他差异。对于大多数适应缓慢和快速的单位来说，这些领域的边界非常尖锐。视野大小变化很大：在10 mm2和600 mm2之间。对于少数的感受器，缓慢以及快速适应的感受器，感受野由高灵敏度的中心和没有明显边界的较低灵敏度的广泛周围区域构成。本研究中遇到的四种类型的受体与亚人灵长类动物中描述的四种不同类型的机械受体具有惊人的相似性，即I型和II型缓慢适应，皮内受体，根据Iggo的术语，皮内快速适应受体和位于皮下组织中的Pacinian小体。大约75%的单位正在慢慢适应。这比在猴子中发现的比例大得多。此外，它显示了如何记录方法提供了机会来分析的感知反应，以及神经生理学反应的一阶神经元机械刺激。
Single unit impulses were recorded from the median and the ulnar nerves in waking human subjects with percutaneously inserted tungsten electrodes. 61 mechanoreceptor units in the glabrous skin were analysed with regard to the characteristics of their receptive fields and the basic physiological properties of their endings. 4 different types of receptors could be distinguished. This distinction was based mainly upon the adaptation and the receptive field characteristics although other differences were also observed. The fields had very sharp borders for the majority of the slowly as well as the rapidly adapting units. The field sizes varied considerably: between 10 mm2and 600 mm2. For a minority of the receptors, slowly as well as rapidly adapting ones, the receptive fields were constituted of a center of high sensitivity and a wide surrounding area of lower sensitivity without distinct borders. The four types of receptors encountered in the present study have striking similarities with four different types of mechano‐receptors which have been described in sub‐human primates, namely the type I and type II slowly adapting, intradermal receptor, according to Iggo's terminology, an intradermal rapidly adapting receptor and the Pacinian corpuscle which is located in the subcutaneous tissues. Roughly 75% of the units were slowly adapting. This is a much larger proportion than found in the monkey. Further, it was shown how the recording method offers the opportunity to analyse the perceptive responses as well as the neurophysiological responses in first order neurons to mechanical stimuli.