18F-FDG PET/CT as an Indicator of Survival in Ewing Sarcoma of Bone
18F-FDG PET/CT as an Indicator of Survival in Ewing Sarcoma of Bone
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DOI：
10.7150/jca.20077
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发表时间：
2017-01-01
影响因子：
3.9
通讯作者：
Costelloe, Colleen M.
中科院分区：
文献类型：
--
作者：
Salem, Usama;Amini, Behrang;Costelloe, Colleen M.
目的：现有文献对18例F-FDG PET/CT在尤文氏肉瘤软组织和骨原发肿瘤患者中的表现进行研究。本研究的目的是评估18F-FDG PET/CT在诱导化疗前后获得的最大标准化摄取值（SUVmax）是否可以作为仅发源于骨骼的Ewing肉瘤患者的生存指标。材料和方法：回顾性检索2004-2011年的数据库，确定28例患者在诱导化疗前（SUV1, n= 28）和诱导化疗后（SUV2, n=23）接受了18次F-FDG PET/CT。平均随访时间为3.3年，幸存者中位随访时间为6.3年（范围：2.6-9.8年）。采用多因素和单因素Cox比例风险模型评估SUV1、SUV2和SUVmax变化与总生存期（OS）和无进展生存期（PFS）的相关性。结果：诱导化疗前（SUV1）和诱导化疗后（SUV2）的平均SUVmax分别为10.74和4.11。高SUV1 （HR=1.05, 95% CI: 1.0-1.1, P = 0.01）和高SUV2 （HR= 1.2, 95% CI: 1.0-1.4, P = 0.01）与较差的OS相关。SUV1的临界值为11.6。SUV1高于11.6时，OS （HR = 5.71, 95% CI: 1.85 ~ 17.61, P = 0.003）和PFS （HR = 3.16, 95% CI: 1.13 ~ 8.79, P = 0.03, P < 0.05有显著性差异）明显恶化。结论：18F-FDG PET/CT可作为原发性骨尤文氏肉瘤的预后指标。
Objective: The existing literature of 18 F-FDG PET/CT in Ewing sarcoma investigates mixed populations of patients with both soft tissue and bone primary tumors. The aim of our study was to evaluate whether the maximum standardized uptake value (SUVmax) obtained with 18F-FDG PET/CT before and after induction chemotherapy can be used as an indicator of survival in patients with Ewing sarcoma originating exclusively in the skeleton.Materials and Methods: A retrospective database search from 2004-2011 identified 28 patients who underwent 18 F-FDG PET/CT before (SUV1, n= 28) and after (SUV2, n=23) induction chemotherapy. Mean follow up was 3.3 years and median follow up for survivors was 6.3 years (range: 2.6-9.8 years). Multivariate and univariate Cox proportional hazard model was used to assess for correlation of SUV1, SUV2, and the change in SUVmax with overall survival (OS) and progression-free survival (PFS).Results: Mean SUVmax was 10.74 before (SUV1) and after 4.11 (SUV2) induction chemotherapy. High SUV1 (HR=1.05, 95% CI: 1.0-1.1, P = 0.01) and SUV2 (HR = 1.2, 95% CI: 1.0-1.4, P = 0.01) were associated with worse OS. A cut off point of 11.6 was identified for SUV1. SUV1 higher than 11.6 had significantly worse OS (HR = 5.71, 95% CI: 1.85 - 17.61, P = 0.003) and PFS (HR = 3.16, 95% CI: 1.13 - 8.79, P = 0.03, P < 0.05 is significant).Conclusion: 18F-FDG PET/CT can be used as a prognostic indicator for survival in primary Ewing sarcoma of bone.