Incidence of adverse drug reactions in geriatric wards of university hospitals
Incidence of adverse drug reactions in geriatric wards of university hospitals
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大学附属医院老年病房药品不良反应发生情况
DOI：
10.3143/geriatrics.41.303
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发表时间：
2004
影响因子：
--
通讯作者：
K. Toba
中科院分区：
文献类型：
--
作者：
M. Akishita;S. Teramoto;Hidenori Arai;Hiroyuki Arai;K. Mizukami;S. Morimoto;K. Toba
老年人的药物不良反应（ADR）随着年龄的增长而增加，通常归因于功能下降和多药治疗。采用多机构回顾性调查方法，对大学医院老年病房药品不良反应的现状进行调查。对5所大学医院2000 ~ 2002年住院患者资料进行分析，共收集1,289例患者。由主治医师确定的ADR发生率总体为9.2%，但各机构的发生率在6.3%至15.8%之间。与ADR发生显著相关的因素有诊断次数、老年综合征次数、处方药次数、入院时增加2种以上药物、住院时间较长、急诊入院、抑郁和冷漠。这些结果与以前的报道基本一致，并将为老年人的药物治疗提供重要信息。
Adverse drug reactions (ADR) in elderly people, which have been shown to increase with age, are often attributed to functional decline and polypharmacy. A multi-institutional retrospective survey was undertaken to investigate the current status of ADR in geriatric wards of university hospitals. The inpatient database from 2000 to 2002 in 5 university hospitals was studied, and a total of 1,289 patients were analyzed. The incidence of ADR, as determined by attending physicians, was 9.2% on the whole but varied from 6.3% to 15.8% among the institutions. The factors significantly related to ADR were number of diagnoses, number of geriatric syndromes, number of prescribed drugs, increase of more than two drugs during admission, longer hospital stay, emergency admission, depression and apathy. These results are mostly consistent with previous reports and will provide important information on pharmacotherapy in elderly people.