Biological functions and theranostic potential of HMGB family members in human cancers.
Biological functions and theranostic potential of HMGB family members in human cancers.
复制标题
DOI：
10.1177/1758835920970850
复制
发表时间：
2020
影响因子：
4.9
通讯作者：
Fan D
中科院分区：
文献类型：
--
作者：
Niu L;Yang W;Duan L;Wang X;Li Y;Xu C;Liu C;Zhang Y;Zhou W;Liu J;Zhao Q;Han Y;Hong L;Fan D
高迁移率组框蛋白（HMGB）家族由HMGB1、2、3和4四个成员组成。它们具有相似的氨基酸序列和相同的功能区域，特别是HMGB1、2和3。结构上的同源性可能导致功能上的相似性。事实上，虽然它们的目标可能不同，但它们都具有结合和扭曲目标dna的基本功能。然而，进一步的研究证实，它们在组织中的分布不同，参与细胞增殖、分裂、迁移和分化等多种不同的生理和病理过程。近年来，HMGB家族成员在肿瘤发生中的作用已被广泛研究；然而，对其在恶性肿瘤中的作用及临床价值的系统探讨尚不多见。本文主要从HMGB家族成员的结构、分布、生化级联以及与肿瘤进展相关的具体机制等方面综述了近年来HMGB家族成员的研究进展。重要的是，讨论了这些蛋白在癌症中的诊断、预后和治疗价值。最后，展望了该领域未来研究的方向和挑战。
The high mobility group box (HMGB) protein family consists of four members: HMGB1, 2, 3, and 4. They share similar amino acid sequences and identical functional regions, especially HMGB1, 2, and 3. The homology in structure may lead to similarity in function. In fact, though their targets may be different, they all possess the fundamental function of binding and distorting target DNAs. However, further research confirmed they are distributed differently in tissues and involved in various distinct physiological and pathological cellular processes, including cell proliferation, division, migration, and differentiation. Recently, the roles of HMGB family members in carcinogenesis has been widely investigated; however, systematic discussion on their functions and clinical values in malignant tumors is limited. In this review, we mainly review and summarize recent advances in knowledge of HMGB family members in terms of structure, distribution, biochemical cascades, and specific mechanisms regarding tumor progression. Importantly, the diagnostic, prognostic, and therapeutic value of these proteins in cancers is discussed. Finally, we envisage the orientation and challenges of this field in further studies.
登录
查看更多内容
DOI：
10.1096/fj.201700013r
发表时间：
2017-07
期刊：
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
影响因子：
--
作者：
Collins PJ;McCully ML;Martínez-Muñoz L;Santiago C;Wheeldon J;Caucheteux S;Thelen S;Cecchinato V;Laufer JM;Purvanov V;Monneau YR;Lortat-Jacob H;Legler DF;Uguccioni M;Thelen M;Piguet V;Mellado M;Moser B
通讯作者：
Moser B
影响因子：
7.7
作者：
Bianco, Christopher;Mohr, Ian
通讯作者：
Mohr, Ian
影响因子：
4.4
作者：
Goh WW;Fan M;Low HS;Sergot M;Wong L
通讯作者：
Wong L
miR-23b-3p通过靶向ATG12和HMGB2调节胃癌细胞的化疗耐药
影响因子：
9
作者：
An Y;Zhang Z;Shang Y;Jiang X;Dong J;Yu P;Nie Y;Zhao Q
通讯作者：
Zhao Q
影响因子：
5.2
作者：
Barreiro-Alonso, Aida;Camara-Quilez, Maria;Cerdan, Maria-Esperanza
通讯作者：
Cerdan, Maria-Esperanza