Fc receptor γ-chain, a constitutive component of the IL-3 receptor, is required for IL-3-induced IL-4 production in basophils
Fc receptor γ-chain, a constitutive component of the IL-3 receptor, is required for IL-3-induced IL-4 production in basophils
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DOI：
10.1038/ni.1686
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发表时间：
2009-02-01
影响因子：
30.5
通讯作者：
Taki, Shinsuke
中科院分区：
文献类型：
--
作者：
Hida, Shigeaki;Yamasaki, Sho;Taki, Shinsuke
Fc受体共同γ -链（FcR γ）是一种广泛表达的适配器，带有免疫受体酪氨酸激活基序（ITAM），可转导来自各种免疫受体的激活信号。我们在这里表明，缺乏FcR γ的嗜碱性细胞在白细胞介素3 （IL-3）的作用下发育正常，增殖有效，但在IL-3诱导的IL-4的产生和支持T辅助型2分化方面受到严重损害。通过其跨膜部分，FcR γ与IL-3受体的公共β链组成性相关，并通过募集激酶Syk来发出信号。逆转录病毒介导的互补证明了FcR γ的ITAM在IL-3信号转导中的重要作用。我们的研究结果确定了一种以前未知的机制，即FcR γ功能将选择性细胞因子触发的信号“路由”到itam介导的IL-4产生途径。
The Fc receptor common gamma-chain (FcR gamma) is a widely expressed adaptor bearing an immunoreceptor tyrosine-based activation motif (ITAM) that transduces activation signals from various immunoreceptors. We show here that basophils lacking FcR gamma developed normally and proliferated efficiently in response to interleukin 3 (IL-3) but were very impaired in IL-3-induced production of IL-4 and in supporting T helper type 2 differentiation. Through its transmembrane portion, FcR gamma associated constitutively with the common beta-chain of the IL-3 receptor and signaled by recruiting the kinase Syk. Retrovirus-mediated complementation demonstrated the essential function of the ITAM of FcR gamma in IL-3 signal transduction. Our results identify a previously unknown mechanism whereby FcR gamma functions to 'route' selective cytokine-triggered signals into the ITAM-mediated IL-4 production pathway.