Electrospinning of type I collagen and PCL nanofibers using acetic acid
Electrospinning of type I collagen and PCL nanofibers using acetic acid
复制标题
DOI：
10.1002/app.36504
复制
发表时间：
2012-08-15
影响因子：
3
通讯作者：
Sekaran, G.
中科院分区：
文献类型：
--
作者：
Chakrapani, V. Yogeshwar;Gnanamani, A.;Sekaran, G.
通过各种技术制造基于天然材料（胶原蛋白、明胶等）的纳米纤维生物材料是一个重要的研究课题。静电纺丝是一种成熟的纳米纤维生产技术，也已扩展到生产天然材料的纳米纤维结构。胶原纳米纤维的生产利用六氟异丙醇 (HFIP) 作为静电纺丝溶剂。目前的研究工作重点是用环境友好的溶剂取代 HFIP。在这项研究中，将牛皮肤的 I 型胶原蛋白与聚己内酯（PCL）作为混合物和环境友好的溶剂乙酸进行静电纺丝。对生产的样品进行接触角测量、孔隙率估计、SEM、FTIR、TGA 和 DSC。生产出 100-200 nm 范围内的纳米纤维，最佳孔隙率为 60%。仪器分析证实了胶原蛋白和 PCL 之间的物理相互作用。我们的研究小组已经在环境友好的溶剂中进行了胶原蛋白的静电纺丝，并且正在研究其在组织工程中的应用。 (C) 2012 年 Wiley 期刊公司。《应用高分子科学》杂志，2012 年
Fabrication of nanofibrous biomaterials based on natural materials (collagen, gelatin, etc.) through various techniques is an important research topic. Electrospinning, a well-established technique for nanofiber production has also been extended for producing nanofibrous structures of natural materials. Collagen nanofiber production utilizes hexafluoro isopropanol (HFIP) as a solvent for electrospinning. Research efforts are now focused on replacing HFIP with an environmentally benign solvent. In this study, electrospinning of Type I collagen of bovine skin with polycaprolactone (PCL) as a blend and an environmentally benign solvent, acetic acid, was carried out. The samples produced were subjected to contact angle measurements, porosity estimation, SEM, FTIR, TGA, and DSC. Nanofibers in the range of 100-200 nm were produced with an optimum porosity of 60%. The instrumental analyses confirm the physical interaction between collagen and PCL. Electrospinning of collagen in an environmentally benign solvent has been carried out and its usage in tissue engineering is being investigated by our research group. (C) 2012 Wiley Periodicals, Inc. J Appl Polym Sci, 2012