SPECIFIC PROGRAMS OF MYOSIN EXPRESSION IN THE POSTNATAL-DEVELOPMENT OF RAT MUSCLES
SPECIFIC PROGRAMS OF MYOSIN EXPRESSION IN THE POSTNATAL-DEVELOPMENT OF RAT MUSCLES
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DOI：
10.1111/j.1432-1033.1989.tb21087.x
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发表时间：
1989-08-15
期刊：
影响因子：
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通讯作者：
ROULET, A
中科院分区：
文献类型：
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作者：
DALBIS, A;COUTEAUX, R;ROULET, A
在大鼠的十几块肌肉中研究了出生后发育过程中肌球蛋白的表达。所有肌肉都表现出从胚胎到新生儿再到成人同肌球蛋白的通常顺序转变。然而，我们观察到这些转变并不是均匀发生的。因此，成年中速肌球蛋白出现的半过渡时间从膈肌（所有检查中最早熟的肌肉）的 7 天延长到雄性大鼠咬肌的 23 天。除了它们的半跃迁时间之间存在巨大差异外，我们注意到过渡曲线显示出不同的斜率，涵盖不同的时期。肌肉之间的差异主要影响新生儿到成人的转变，而不是胚胎到新生儿的转变，因为胚胎型肌球蛋白从所有检查的肌肉中消失，除了一块之外，大约在同一时间，在出生后第一周结束时。此外，每块肌肉的慢速肌球蛋白的外观各不相同，并且不遵循与中速肌球蛋白和快速肌球蛋白平行的曲线。这些结果表明，大鼠的每块肌肉在出生后发育过程中都经历特定的肌球蛋白亚型转变程序。
The expression of myosin during postnatal development was studied in a dozen muscles of the rat. All muscles displayed the usual sequential transitions from embryonic to neonatal and to adult isomyosins. However, we observed that these transitions did not take place uniformly. Thus, half-transition times for the appearance of the adult intermediate and fast myosin extended from seven days for diaphragm, the most precocious muscle of all those examined, to 23 days for male rat masseter. Besides the large differences between their half-transition times, we noticed that the transition curves displayed different slopes, covering different periods. Differences between muscles mainly affected the neonatal-to-adult transition rather than the embryonic-to-neonatal transition, since the embryonic-type myosin disappeared from all muscles examined except for one, at about the same time, by the end of the first week after birth. In addition, the appearance of slow myosin varied for each muscle and did not follow curves parallel to those for intermediate and fast myosins. These results indicate that each muscle of the rat is subjected to a specific program of myosin isoform transitions during postnatal development.