Correlation of weight-based i.v. immune globulin doses with changes in serum immunoglobulin G levels
Correlation of weight-based i.v. immune globulin doses with changes in serum immunoglobulin G levels
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DOI：
10.2146/ajhp140171
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发表时间：
2015-02-15
影响因子：
2.7
通讯作者：
Olson, Jared A.
中科院分区：
文献类型：
--
作者：
Anderson, Collin R.;Olson, Jared A.
目的。 i.v. 之间的相关性研究了三种基于体重的给药方法下免疫球蛋白（IVIG）剂量和血清免疫球蛋白G（IgG）浓度的变化。进行了回顾性病历审查，以确定多中心医疗保健系统中在 10 年期间接受 IVIG 并在 IVIG 给药日期前两天和给药日期后两天内进行血清 IgG 测量的患者。对于确定的 11 名成人和 7 名青少年，评估了基于体重的 IVIG 剂量（使用实际体重 [BW]、调整后的 BW 或理想 BW [IBW] 确定）与由此产生的血清 IgG 变化之间的关系。计算并比较了三种给药方法的相关系数和相应的 p 值。结果。在成年患者中，IVIG 剂量和服药后血清 IgG 变化的相关性在 IBW 给药时最强（相关系数 [r] 为 0.83 [p < 0.05]，而调整 BW 或实际 BW 给药的 r 值分别为 0.73 和 0.70 [两者 p = 0.05]）；青少年患者的相应 r 值分别为 0.99、0.99 和 0.95（全部 p < 0.005）。在成人或青少年中，三种基于体重的给药方法计算的 r 值之间没有统计学上的显着差异。结论。在成年患者中，当使用 IBW 计算剂量时，IVIG 剂量与 IgG 水平变化之间的相关性最强；在青少年群体中，三种基于体重的给药评估方法观察到了相当程度的相关性。
Purpose. Correlations between the i.v. immune globulin (IVIG) dose and the change in serum immunoglobulin G (IgG) concentration with three methods of weight-based dosing were investigated.Methods. A retrospective medical records review was conducted to identify patients in a multicenter healthcare system who received IVIG over a 10-year period and had serum IgG measurements within two days before and two days after the date of IVIG administration. For each of the 11 adults and 7 adolescents identified, the relationship between the weight-based dose of IVIG (determined using actual body weight [BW], adjusted BW, or ideal BW [IBW]) and the resulting change in serum IgG was evaluated. Correlation coefficients and corresponding p values for the three dosing methods were calculated and compared.Results. Among adult patients, the correlation of IVIG dose and postdose change in serum IgG was strongest with dosing by IBW (correlation coefficient [r], 0.83 [p < 0.05] versus r values of 0.73 and 0.70 for dosing by adjusted BW or actual BW, respectively [p = 0.05 for both]); the corresponding r values in adolescent patients were 0.99, 0.99, and 0.95, respectively (p < 0.005 for all). There were no statistically significant differences between the r values calculated for the three weight-based dosing methods in either adults or adolescents.Conclusion. In adult patients, the correlation between the dose of IVIG and the change in IgG level was strongest when doses were calculated using IBW; comparable degrees of correlation were observed with the three evaluated methods of weight-based dosing in the adolescent population.