Helicobacter pylori BabA in adaptation for gastric colonization.
Helicobacter pylori BabA in adaptation for gastric colonization.
复制标题
DOI：
10.3748/wjg.v23.i23.4158
复制
发表时间：
2017-06-21
影响因子：
4.3
通讯作者：
Yamaoka Y
中科院分区：
文献类型：
--
作者：
Ansari S;Yamaoka Y
幽门螺杆菌(Hp)作为一种胃并发症的病原体，非常适合胃粘膜的定植。虽然感染过程取决于多种因素，但与胃粘膜的粘连是第一步，也是重要的一步。在几种外膜蛋白中，BABA是参与许多炎症过程的重要蛋白之一，此外它还参与持久定植的附着作用。应用计算机检索PubMed，检索词：“Baba”、“Pylori”、“胃部并发症”、“同源重组”、“滑链错配”，共显示249篇文章。其中，我们主要关注2005至2016年间发表的全文为英文的文章。幽门螺杆菌BABA参与与受体的结合，但其合成受时相变化的调节。在这篇综述中，我们证实了幽门螺杆菌BABA可以在分子和功能水平上进行调节，以适应胃肠道内的压力。
Helicobacter pylori (H. pylori) as a causative agent of gastric complications, is well adapted for the colonization of gastric mucosa. Although the infectious process depends on several factors, the adhesion to the gastric mucosa is the first and important step. Among several outer membrane proteins, BabA is one of the significant protein involving in many inflammatory processes in addition to its role in the attachment for the persistent colonization. We performed a PubMed search using the key words: “babA”, “pylori”, “gastric complications”, “homologous recombination”, “slipped strand mispairing”; a total of 249 articles were displayed. Of these we mainly focused on articles with the full text in English and published between 2005 and 2016. H. pylori BabA is involved in binding with receptors; however, its synthesis is regulated by phase variation. In this review we confirm that H. pylori babA can be modulated at the molecular and functional levels to adapt to the stress within the gastro-intestinal tract.