In vitro study of drug accumulation in cancer cells via specific association with CdS nanoparticles
In vitro study of drug accumulation in cancer cells via specific association with CdS nanoparticles
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通过与 CdS 纳米粒子的特异性结合进行癌细胞内药物积累的体外研究
DOI：
10.1016/j.bmcl.2006.06.069
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发表时间：
2006-09-15
影响因子：
2.7
通讯作者：
Wang, Xuemei
中科院分区：
文献类型：
--
作者：
Li, Jingyuan;Wu, Chunhul;Wang, Xuemei
我们报告了一种通过与美国纳米粒子结合来增强抗癌药物柔红霉素在癌细胞上的有效积累和利用的新方法。我们使用共焦荧光扫描显微镜和电化学分析方法的观察表明，CdS 纳米颗粒可以很容易地与靶细胞外膜上的柔红霉素结合，并促进人白血病 K562 细胞对药物分子的摄取。此外，我们的结果还表明，美国纳米粒子与伴随的抗癌药物竞争性结合到白血病K562细胞膜上，可以有效阻止药物敏感和耐药的白血病细胞的药物释放，从而抑制癌细胞可能的多药耐药性，这可以进一步用于提高未来各肿瘤化疗的药物效率。 (c) 2006 Elsevier Ltd. 保留所有权利。
We report a novel approach to enhance the efficient accumulation and utilization of anticancer drug daunorubicin on cancer cells through the combination with US nanoparticles. Our observations using confocal fluorescence scanning microscopy as well as electrochemical analysis methods demonstrate that CdS nanoparticles can readily bind with daunorubicin on the external membrane of the targeted cells and facilitate the uptake of drug molecules in the human leukemia K562 cells. Besides, our results also indicate that the competitive binding of US nanoparticles with accompanying anticancer drug to the membrane of leukemia K562 cells could efficiently prevent the drug release by the drug-sensitive and drug-resistant leukemia cells and thus inhibit the possible multidrug resistance of cancer cells, which could be further utilized to improve the future drug efficiency in respective tumor chemotherapies. (c) 2006 Elsevier Ltd. All rights reserved.