In vivo quantification of hippocampal subfields using 4.7 T fast spin echo imaging
In vivo quantification of hippocampal subfields using 4.7 T fast spin echo imaging
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DOI：
10.1016/j.neuroimage.2009.09.042
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发表时间：
2010-01-15
期刊：
影响因子：
5.7
通讯作者：
Carter, R.
中科院分区：
文献类型：
--
作者：
Malykhin, N. V.;Lebel, R. M.;Carter, R.
几种涉及海马结构变化的神经精神疾病已经使用体积磁共振成像（MRI）进行了广泛的研究。这些研究大多测量海马总体积，而本研究旨在描绘和测量整个海马内的海马亚区和沿其纵轴沿着的细分。在4.7 T条件下，对11名健康受试者（5名男性和6名女性，年龄23-56岁）使用快速自旋回波（FSE）序列（原始分辨率为0.52 x 0.68 x 1.0 mm（3））采集图像，收集90个连续冠状切片。海马下托，角ammonis（CA 1 -3），和齿状回内的海马头部，身体和尾部手动跟踪。我们报告了子场的体积，并证明了海马及其部分内分布的差异。海马齿状回最大的部分位于海马体，位于海马头、尾之后。而海马头部的CA 1 -3区面积最大，其次是海马体和海马尾。海马尾的海马下托的最小部分相比，海马头部和尾部。子视野体积在半球之间是一致的，并且显示出与组织学数据一致的纵向细分内的分布。沿海马体纵轴沿着的子域分布的直接测量可能比总体积测量更敏感地检测疾病影响，子域体积的差分分布可能有助于解释在较低的保持强度和空间分辨率下获得的测量结果。(C)2009 Elsevier Inc.所有战斗保留。
Several neuropsychiatric disorders involving hippocampal structural changes have been studied extensively using volumetric magnetic resonance imaging (MRI). These studies have mostly measured total hippocampal volume while the present study aimed to delineate and measure hippocampal subfields within the whole hippocampus and subdivisions along its longitudinal axis. Images were acquired at 4.7 T in 11 healthy subjects (5 males and 6 females, aged 23-56 years), using a fast spin echo (FSE) sequence with 0.52 x 0.68 x 1.0 mm(3) native resolution, collecting 90 contiguous coronal slices. Subiculum, cornu ammonis (CA1-3), and dentate gyrus were traced manually within the hippocampal head, body, and tail. We reported volumes for the subfields and demonstrated differences in the distribution within the hippocampus and its parts. The biggest part of the dentate gyrus was located in the hippocampal body, following the hippocampal head and tail. In contrast, the hippocampal head had the largest part of CA1-3, following the hippocampal body and tail. The hippocampal tail had the smallest portion of the subiculum compared to hippocampal head and tail. Subfield volumes were consistent between hemispheres and showed distributions within the longitudinal Subdivisions that were consistent with histological data. Direct measurements of subfield distribution along the longitudinal axis of the hippocampus may be more sensitive to detecting disease effects than total volume measures and the differential distribution of subfield volumes may aid in the interpretation of measurements obtained at lower Held strength and spatial resolution. (C) 2009 Elsevier Inc. All Fights reserved.