EFFECT OF SUPERSATURATION ON MEMBRANE-TRANSPORT .1. HYDROCORTISONE ACETATE
EFFECT OF SUPERSATURATION ON MEMBRANE-TRANSPORT .1. HYDROCORTISONE ACETATE
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DOI：
10.1016/0378-5173(91)90337-n
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发表时间：
1991-09-30
影响因子：
5.8
通讯作者：
HADGRAFT, J
中科院分区：
文献类型：
--
作者：
DAVIS, AF;HADGRAFT, J
在体外，醋酸氢化可的松跨模型合成膜的转运进行了研究。通过混合适当的丙二醇/水共溶剂系统形成的醋酸氢化可的松的亚饱和、饱和和过饱和溶液。研究了在研究的宽范围内，运输与饱和度成线性比例。过饱和系统在局部药物递送中具有潜在的应用，特别是当从饱和溶液中的释放受到限制时。
In vitro, the transport of hydrocortisone acetate across a model synthetic membrane has been investigated. Subsaturated, saturated and supersaturated solutions of hydrocortisone acetate, formed by mixing appropriate propylene glycol/water cosolvent systems. were studied. Transport was linearly proportional to the degree of saturation over the wide range studied. Supersaturated systems have potential application in topical drug delivery especially when release from saturated solutions is limiting.