The long-term effects of institutional rearing, foster care intervention and disruptions in care on brain electrical activity in adolescence
The long-term effects of institutional rearing, foster care intervention and disruptions in care on brain electrical activity in adolescence
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DOI：
10.1111/desc.12872
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发表时间：
2020-01-01
影响因子：
3.7
通讯作者：
Fox, Nathan A.
中科院分区：
文献类型：
--
作者：
Debnath, Ranjan;Tang, Alva;Fox, Nathan A.
由于机构护理而导致的早期心理社会剥夺会扰乱典型的大脑发育。布加勒斯特早期干预项目(BEIP)是第一项纵向研究，调查随机接受寄养(FCG)干预和照常护理(CAUG)的住院婴儿的神经发育。在这里，我们提出了一项追踪评估脑电活动的结果，该评估以16岁时的静息脑电为指标。此外，我们还研究了寄养安置中断(例如寄养安置之间的迁移次数)对脑电活动的影响。静息状态脑电来自48名CAUG、46名FCG和48名从未住院(NIG)的对照组参与者。绝对功率(MU V-2)和相对功率(比例)是从闭眼休息的脑电数据中计算出来的，这些数据涉及theta、α和β频段。在16岁时，与FCG相比，CAUG显示出更高的相对theta和更低的相对α功率。FCG显示的大脑活动与NIG相当。结果进一步表明，最初寄养后的干扰对脑电活动有不利影响。在寄养组中，安置年龄对脑电功率没有影响。将经历早期机构抚养的儿童安置在稳定的寄养环境中，确保大脑功能的长期改善。
Exposure to early psychosocial deprivation as a result of institutional care disrupts typical brain development. The Bucharest Early Intervention Project (BEIP) is the first longitudinal study to investigate the neurodevelopment of institutionalized infants randomized to a foster care (FCG) intervention versus care as usual (CAUG). Here, we present findings from a follow-up assessment of brain electrical activity as indexed by resting EEG at age 16 years. In addition, we examined the effects of disruption of foster care placement (e.g. the number of moves among foster care placements) on brain electrical activity. Resting-state EEG was collected from 48 CAUG, 46 FCG and 48 never institutionalized (NIG) control participants. Absolute (mu V-2) and relative (proportion) power were computed from eyes closed, resting EEG data for theta, alpha and beta frequency bands. The CAUG displayed higher relative theta and lower relative alpha power compared to the FCG at 16 years of age. The FCG showed brain activity comparable to the NIG. The results further showed that disruptions following the original foster care placement had an adverse effect on brain electrical activity. Within the foster care group, there were no effects of age of placement on EEG power. Placement of children who have experienced early institutional rearing into stable foster care settings ensure long-term improvement in brain functioning.