Molecular pathogenesis of hepatocellular carcinoma and impact of therapeutic advances.
Molecular pathogenesis of hepatocellular carcinoma and impact of therapeutic advances.
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DOI：
10.12688/f1000research.6946.1
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发表时间：
2016-01-01
期刊：
影响因子：
--
通讯作者：
Roberts, Lewis R
中科院分区：
文献类型：
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作者：
Dhanasekaran, Renumathy;Bandoh, Salome;Roberts, Lewis R
肝细胞癌是导致癌症死亡的主要原因，在全球范围内发病率呈上升趋势。肝细胞癌可由多种病因诱发，受多种危险因素影响，发病机制复杂。此外，肝细胞癌表现出很大的异质性，这增加了针对这种高度致命的癌症开发有效疗法的难度。随着癌症生物学和分子遗传学研究的进展，许多不同的机制参与了肝细胞癌的发生和发展。尽管在这一领域取得了进展，但肝细胞癌的分子发病机制仍不完全清楚。本文旨在阐述我们目前对肝细胞癌发生和发展过程中最相关的基因改变和分子通路的理解，并预测未来的研究进展对治疗药物开发的潜在影响。
Hepatocellular carcinoma (HCC) is a leading cause of cancer mortality and has an increasing incidence worldwide. HCC can be induced by multiple etiologies, is influenced by many risk factors, and has a complex pathogenesis. Furthermore, HCCs exhibit substantial heterogeneity, which compounds the difficulties in developing effective therapies against this highly lethal cancer. With advances in cancer biology and molecular and genetic profiling, a number of different mechanisms involved in the development and progression of HCC have been identified. Despite the advances in this area, the molecular pathogenesis of hepatocellular carcinoma is still not completely understood. This review aims to elaborate our current understanding of the most relevant genetic alterations and molecular pathways involved in the development and progression of HCC, and anticipate the potential impact of future advances on therapeutic drug development.