A pivotal role for interferon-gamma in protection against group A streptococcal skin infection.
A pivotal role for interferon-gamma in protection against group A streptococcal skin infection.
复制标题
干扰素-γ 在预防 A 组链球菌皮肤感染方面发挥着关键作用。
DOI：
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发表时间：
2000
期刊：
影响因子：
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通讯作者：
D. Metzger
中科院分区：
文献类型：
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作者：
R. Raeder;L. Barker;T. Lester;M. Boyle;D. Metzger
外源性重组白细胞介素-12（rIL-12）的给药，无论是预防性还是治疗性的，都能在小鼠模型中提供针对致死性A组链球菌皮肤感染的显著保护。在用A组链球菌感染之前用rIL-12处理小鼠诱导了干扰素-γ（IFN-γ）在感染部位的表达。体内IFN-γ的中和作用增加了对致死性感染的易感性，并完全消除了rIL-12的保护作用。IFN-γ基因敲除小鼠也更容易受到致命感染。虽然IL-12治疗提供了保护，但较高剂量诱导IFN-γ转录水平显著升高，这与对致死性感染的易感性增加有关。这些结果支持的假设，IFN-γ在感染部位是至关重要的保护，但表明，增加全身水平是有害的生存后，感染A组链球菌。
Administration of exogenous recombinant interleukin-12 (rIL-12) either prophylactically or therapeutically provides significant protection against lethal group A streptococcal skin infection in a mouse model. Treatment of mice with rIL-12 before infection with group A streptococci induced expression of interferon-gamma (IFN-gamma) at the infection site. In vivo neutralization of IFN-gamma increased susceptibility to lethal infection and completely abrogated the protective effects of rIL-12. IFN-gamma knockout mice were also more susceptible to lethal infection. Although IL-12 treatment provided protection, higher doses induced significantly elevated levels of IFN-gamma transcription that were associated with increased susceptibility to lethal infection. These results support the hypothesis that IFN-gamma at the infection site is critical for protection but suggest that increased systemic levels are detrimental to survival after infection with group A streptococci.