TETROCARCINS, NOVEL ANTITUMOR ANTIBIOTICS
TETROCARCINS, NOVEL ANTITUMOR ANTIBIOTICS
复制标题
四癌素，新型抗肿瘤抗生素
DOI：
--
复制
发表时间：
1980
期刊：
影响因子：
--
通讯作者：
T. Tamaoki
中科院分区：
文献类型：
--
作者：
F. Tomita;T. Tamaoki
从日本宫城仙台的土壤样品中分离出放线菌DO-11（KY 11091）的培养液中获得了一种新的抗肿瘤抗生素复合物。在分类学研究中，生产微生物被描述为Micromonospora chalcea KY 11091。可溶性淀粉是该抗生素产生的良好碳源，酵母膏是最佳氮源。指定为tetrocarcins的抗生素复合物对革兰氏阳性细菌有活性，但对革兰氏阴性细菌没有活性。Tetrocarcin A对枯草芽孢杆菌具有杀菌活性。
A novel antitumor antibiotic complex has been obtained from the culture broth of Actinomycete strain DO-11 (KY11091) isolated from a soil sample collected in Sendai, Miyagi, Japan. On the taxonomic studies the producing organism is described as Micromonospora chalcea KY11091. For the production of the antibiotics, soluble starch served as a good carbon source and yeast extract was the best nitrogen source tested. The antibiotic complex designated as tetrocarcins is active against Gram-positive bacteria, but is not active against Gram-negative bacteria. Tetrocarcin A showed bacteriocidal activity against Bacillus subtilis.