Competition in retinogeniculate patterning driven by spontaneous activity
Competition in retinogeniculate patterning driven by spontaneous activity
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DOI：
10.1126/science.279.5359.2108
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发表时间：
1998-03-27
期刊：
影响因子：
56.9
通讯作者：
Shatz, CJ
中科院分区：
文献类型：
--
作者：
Penn, AA;Riquelme, PA;Shatz, CJ
当接触在发育中的神经系统中第一次形成时，许多神经元产生自发的活动，这些活动被假设为形成适当的模式连接。在疖Mustela putorius furo中，胆碱能药物对自发视网膜动作电位波的单眼内阻断改变了随后的外侧膝状核（LGN）的眼部特异性层压模式。活动视网膜的投影大大扩展到通常属于另一只眼睛的区域，而非活动视网膜的投影则大大减少。因此，由内源性视网膜活动驱动的眼间竞争决定了从视网膜到LGN的眼睛特异性连接模式，这表明自发活动可以在视觉体验开始之前产生高度定型的连接模式。
When contacts are first forming in the developing nervous system, many neurons generate spontaneous activity that has been hypothesized to shape appropriately patterned connections. In Mustela putorius furo, monocular intraocular blockade of spontaneous retinal waves of action potentials by cholinergic agents altered the subsequent eye-specific lamination pattern of the lateral geniculate nucleus (LGN). The projection from the active retina was greatly expanded into territory normally belonging to the other eye, and the projection from the inactive retina was substantially reduced. Thus, interocular competition driven by endogenous retinal activity determines the pattern of eye-specific connections from retina to LGN, demonstrating that spontaneous activity can produce highly stereotyped patterns of connections before the onset of visual experience.