PXR haplotype clusters will affect the pharmacokinetics of ciclosporin in Chinese renal transplant recipients
PXR haplotype clusters will affect the pharmacokinetics of ciclosporin in Chinese renal transplant recipients
复制标题
PXR单倍型簇将影响环孢素在中国肾移植受者中的药代动力学
DOI：
10.1111/jphp.13206
复制
发表时间：
2019-12-09
影响因子：
3.3
通讯作者：
Ge, Weihong
中科院分区：
文献类型：
--
作者：
Li, Danying;Zhu, Huaijun;Ge, Weihong
PXR是调节代谢酶和转运蛋白表达的关键核受体。本研究的目的是评估PXR单倍型簇对中国肾移植受者移植后早期环孢素浓度的影响。
PXR was reported to be the key nuclear receptor regulating the expression of metabolizing enzymes and transporters. The aim of this study was to evaluate the influence of PXR haplotype clusters on ciclosporin concentration in Chinese renal transplant recipients during the early stage after transplantation.