A3 adenosine receptor: pharmacology and role in disease.
A3 adenosine receptor: pharmacology and role in disease.
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DOI：
10.1007/978-3-540-89615-9_10
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发表时间：
2009-01-01
影响因子：
--
通讯作者：
Fishman, P
中科院分区：
文献类型：
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作者：
Borea, P A;Gessi, S;Fishman, P
A（3）腺苷受体（A（3）AR）的研究代表了腺苷领域中快速增长和密集的研究领域。本章将概述这种A（3）AR亚型在病理生理条件下的表达模式、分子药理学和功能作用。通过使用选择性A（3）AR激动剂和拮抗剂或A（3）AR敲除小鼠的研究，现在清楚的是，该受体在缺血性疾病以及炎症和自身免疫性病理学的调节中起关键作用。因此，还将描述激动剂和拮抗剂的潜在治疗用途。讨论将主要涉及这些化合物在治疗脑和心脏缺血、哮喘、脓毒症和青光眼中的用途。最后一部分集中在A（3）AR在自身免疫性疾病，如类风湿性关节炎的分子基础，并包括一个选择性激动剂CF 101的临床试验的描述。基于本章，很明显，继续研究发现A（3）AR亚型的激动剂和拮抗剂是必要的。
The study of the A(3) adenosine receptor (A(3)AR) represents a rapidly growing and intense area of research in the adenosine field. The present chapter will provide an overview of the expression patterns, molecular pharmacology and functional role of this A(3)AR subtype under pathophysiological conditions. Through studies utilizing selective A(3)AR agonists and antagonists, or A(3)AR knockout mice, it is now clear that this receptor plays a critical role in the modulation of ischemic diseases as well as in inflammatory and autoimmune pathologies. Therefore, the potential therapeutic use of agonists and antagonists will also be described. The discussion will principally address the use of such compounds in the treatment of brain and heart ischemia, asthma, sepsis and glaucoma. The final part concentrates on the molecular basis of A(3)ARs in autoimmune diseases such as rheumatoid arthritis, and includes a description of clinical trials with the selective agonist CF101. Based on this chapter, it is evident that continued research to discover agonists and antagonists for the A(3)AR subtype is warranted.