Development of fulminant Type 1 diabetes with thrombocytopenia after influenza vaccination: a case report
Development of fulminant Type 1 diabetes with thrombocytopenia after influenza vaccination: a case report
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DOI：
10.1111/j.1464-5491.2011.03391.x
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发表时间：
2012-01-01
影响因子：
3.5
通讯作者：
Yokono, K.
中科院分区：
文献类型：
--
作者：
Yasuda, H.;Nagata, M.;Yokono, K.
暴发性1型糖尿病最初被报道为特发性1型糖尿病。病毒感染参与暴发性T1 D的发病机制，但流感疫苗接种后暴发性1型糖尿病的发展尚未报道。病例报告我们报告一例暴发性1型糖尿病伴血小板减少症后接种流感疫苗。一名54岁男子因高血糖症和糖尿病酮症入院。入院前7天，他接种了季节性流感疫苗，以预防流感感染。入院时，血糖为29 mmol/L，HbA 1c为40 mmol/mol（5.9%）。空腹和2小时C肽免疫反应性为
Background Fulminant Type 1 diabetes was originally reported as idiopathic Type 1 diabetes. Involvement of viral infections in the pathogenesis of fulminant T1D has been suggested, but the development of fulminant Type 1 diabetes after influenza vaccination has not been reported. Case Report We report a case of fulminant Type 1 diabetes with thrombocytopenia following influenza vaccination. A 54-year-old man was admitted to hospital with hyperglycaemia and diabetic ketosis. Seven days before admission, he received a seasonal influenza vaccine for the prevention of influenza infection. On admission, blood glucose was 29 mmol/L and HbA1c 40 mmol/mol (5.9%). Fasting and 2-h C-peptide immunoreactivity were