Preference procedures for testing the abuse liability of drugs in humans.
Preference procedures for testing the abuse liability of drugs in humans.
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测试人类药物滥用倾向的优先程序。
DOI：
10.1111/j.1360-0443.1991.tb01751.x
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
DeWit,H
中科院分区：
文献类型：
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作者：
DeWit,H
药物偏好程序可用于评估人类志愿者的药物滥用责任。这些程序通常在受控的双盲条件下测量受试者对药物和安慰剂的选择。根据研究的条件（例如，受试者群体，测试的环境条件），在这些实验室程序中，已知被滥用的药物也是首选的。为了评估未知试验药物的滥用可能性，将选择试验药物的频率与已知滥用可能性的标准药物的选择进行比较：相对于标准药物，对试验药物的偏好被视为其相对滥用可能性的指标。在设计和解释选择研究时，必须考虑许多方法学上的变量，包括受试者的特征、试验剂量范围、选择是间隔很大（例如一天一个）还是间隔很近（例如一个接一个），以及研究是在受控的实验室条件下进行还是在受试者正常的日常环境中进行。测试未知化合物滥用倾向性的条件必须根据已有的类似已知滥用药物的文献来选择。
Drug preference procedures may be used to assess the abuse liability of drugs in human volunteers. These procedures usually measure subjects' choice of a drug versus a placebo, under controlled, double‐blind conditions. Depending upon the conditions of the studies (e.g. subject population, environmental conditions of testing), drugs that are known to be abused are also preferred in these laboratory procedures. To assess the abuse liability of an unknown test drug, the frequency of choice of the test drug is compared to choice of a standard drug with known abuse potential: preference for the test drug, relative to the standard, is then taken as an indicator of its relative potential for abuse. A number of methodological variables must be considered when designing and interpreting choice studies, including the characteristics of the subjects, the range of doses tested, whether choices were spaced widely apart (e.g. one a day) or closely together (e.g. one immediately after another), and whether the study was conducted under controlled laboratory conditions or in the subjects' normal daily environments. The conditions for testing the abuse liability of an unknown compound must be selected based on the existing literature with similar, known drugs of abuse.