Hepatitis-associated antigen in Ugandan patients with hepatocellular carcinoma.
Hepatitis-associated antigen in Ugandan patients with hepatocellular carcinoma.
复制标题
乌干达肝细胞癌患者的肝炎相关抗原。
DOI：
10.1016/s0140-6736(70)91396-6
复制
发表时间：
1970
期刊：
影响因子：
168.9
通讯作者：
L. Barker
中科院分区：
文献类型：
--
作者：
CharlesL. Vogel;N. Mody;P. Anthony;L. Barker
45 名乌干达肝细胞癌患者中的 18 名 (40%) 和 122 名对照患者中的 4 名 (3%) 肝炎相关抗原 (H.A.A.) 补体结合试验呈阳性。患有肝细胞癌的 H.A.A. 阳性个体有甲胎蛋白阳性的趋势，并且有潜在的“肝炎后”型肝硬化。年轻患者往往是 H.A.A.阳性率高于老年患者。这些数据支持了以下假设：先前的病毒性肝炎感染可能在乌干达肝细胞癌的病因学和发病机制中发挥一定作用。
18 of 45 (40%) Ugandan patients with Shepatocellular carcinoma and 4 of 122 (3%) control patients had positive complement-fixation tests for hepatitis-associated antigen (H.A.A.). There was a tendency for H.A.A.-positive individuals with hepatocellular carcinoma to be α-fetoprotein positive and to have underlying cirrhosis of the "posthepatitic" type. Young patients tended to be H.A.A. positive more frequently than old patients. The data provide support for the hypothesis that antecedent viral-hepatitis infection may play some role in the ætiology and pathogenesis of hepatocellular carcinoma in Uganda.