In vivo trabecular bone morphologic and mechanical relationship using high-resolution 3-T MRI
In vivo trabecular bone morphologic and mechanical relationship using high-resolution 3-T MRI
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DOI：
10.2214/ajr.07.3528
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发表时间：
2008-09-01
影响因子：
5
通讯作者：
Moratal, David
中科院分区：
文献类型：
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作者：
Alberich-Bayarri, Angel;Marti-Bonmati, Luis;Moratal, David
OBJECTIVE.本研究的目的是调查在体内骨小梁的形态和弹性参数与高分辨率3-T MRI在健康的参考population.Subjects和方法。一系列的手腕MR图像采集与高spatialresolution（180 μ m）各向同性体素从40名受试者没有报告的骨疾病。图像后处理后，在形态学分析中计算骨体积与总体积的比率、骨小梁厚度、骨小梁分离和骨小梁数量。采用有限元法对松质骨进行力学模拟，计算表观弹性模量参数。研究了形态参数与力学参数之间的关系。还研究了分析的骨体积的影响。统计学上显著的性别影响被发现的骨体积与总体积比（p = 0.003），骨小梁厚度（p = 0.02），和表观弹性模量（p = 0.01）;这些参数在女性中较低。然而，仅在小梁分离（p = 0.06）和小梁数量（p = 0.07）上发现了趋势。年龄在任何形态学方面均无统计学显著影响。（骨体积/总体积比，r =-0.24，p = 0.13;骨小梁厚度，r =-0.03，p = 0.88;骨小梁分离，r = 0.12，p = 0.47;和骨小梁数，r =-0.23，p = 0.16）或弹性（表观弹性模量，r =-0.18，p = 0.26）参数。表观弹性模量与骨体积/总体积比的平方之间存在统计学显著相关性（r = 0.968，p < 0.001）。未观察到这种相关性（r = 0.185，p = 0.25），如果分析的骨体积减少，表观弹性模量结果有显著差异（p < 0.001）。我们发现，骨体积与总体积比，骨小梁厚度和表观弹性模量的参数受性别的显着影响。表观弹性模量结果显示与骨体积与总体积比的关系。为了进行适当的力学分析，应最大化松质骨体积。
OBJECTIVE. The purpose of this study was to investigate the in vivo morphologic and elastic parameters of trabecular bone with high-resolution 3-T MRI in a healthy reference population.SUBJECTS AND METHODS. A series of wrist MR images were acquired with high-spatialresolution (180 mu m) isotropic voxels from 40 subjects without reported bone disease. After image postprocessing, the bone volume-to-total volume ratio, trabecular thickness, trabecular separation, and trabecular number were calculated in the morphologic analysis. Trabecular bone was mechanically simulated using the finite-element method to calculate the apparent elastic modulus parameter. The relationship between morphologic and mechanical parameters was studied. The influence of the analyzed bone volume was also investigated.RESULTS. Statistically significant sex influences were found on the bone volume-to-total volume ratio (p = 0.003), trabecular thickness (p = 0.02), and apparent elastic modulus (p = 0.01); these parameters were lower in women. However, trends were found only on trabecular separation (p = 0.06) and trabecular number (p = 0.07). Age had no statistically significant influence in any morphologic (bone volume-to-total volume ratio, r = -0.24, p = 0.13; trabecular thickness, r = -0.03, p = 0.88; trabecular separation, r = 0.12, p = 0.47; and trabecular number, r = -0.23, p = 0.16) or elastic (apparent elastic modulus, r = -0.18, p = 0.26) parameter. A statistically significant relationship between apparent elastic modulus and the square of bone volume-to-total volume ratio was found (r = 0.968, p < 0.001). This association was not seen (r = 0.185, p = 0.25) and apparent elastic modulus results were considerably different (p < 0.001) if the volume of analyzed bone was reduced.CONCLUSION. We found that bone volume-to-total volume ratio, trabecular thickness, and apparent elastic modulus are parameters significantly influenced by sex. Apparent elastic modulus results show a relationship with bone volume-to-total volume ratio. Trabecular bone volume should be maximized for an appropriate mechanical analysis.