A three-dimensional graphene oxide supramolecular hydrogel for infrared light-responsive cascade release of two anticancer drugs
A three-dimensional graphene oxide supramolecular hydrogel for infrared light-responsive cascade release of two anticancer drugs
复制标题
三维氧化石墨烯超分子水凝胶用于红外光响应级联释放两种抗癌药物
DOI：
10.1039/c6cc08123a
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发表时间：
2016-01-01
影响因子：
4.9
通讯作者：
Shi, Yan-Ping
中科院分区：
文献类型：
--
作者：
Ha, Wei;Zhao, Xiao-Bo;Shi, Yan-Ping
开发了一种由前药修饰的氧化石墨烯和α-环糊精组成的三维超分子水凝胶。该水凝胶具有良好有序的内部微观结构，将疏水性和亲水性抗癌药物整合到单个多功能平台中，并在NIR光照射后经历凝胶-溶胶转变，导致两种药物以按需方式级联释放。
A three dimensional supramolecular hydrogel consisting of prodrug-modified graphene oxide and alpha-cyclodextrin was developed. This hydrogel with a well-ordered interior microstructure integrated hydrophobic and hydrophilic anticancer drugs into a single multifunctional platform, and underwent a gel-sol transition leading to cascade release of two drugs in an on-demand fashion upon NIR light irradiation.